{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(5)"],"submitter":["Poller W"],"pubmed_abstract":["SCN5A was considered an exclusively cardiac expressed ion channel but discovered to also act as a novel innate immune sensor. We report on a young SCN5A variant carrier with recurrent ventricular fibrillation and massive myocardial inflammation whose peculiar clinical course is highly suggestive of such a dual role of SCN5A. (<b>Level of Difficulty: Advanced.</b>)."],"journal":["JACC. Case reports"],"pagination":["280-286"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897185"],"repository":["biostudies-literature"],"pubmed_title":["Missense Variant E1295K of Sodium Channel SCN5A Associated With Recurrent Ventricular Fibrillation and Myocardial Inflammation."],"pmcid":["PMC8897185"],"pubmed_authors":["Escher F","Attanasio P","Meder B","Haas J","Skurk C","Schultheiss HP","Poller W","Haghikia A","Heidecker B","Klaassen S"],"additional_accession":[]},"is_claimable":false,"name":"Missense Variant E1295K of Sodium Channel SCN5A Associated With Recurrent Ventricular Fibrillation and Myocardial Inflammation.","description":"SCN5A was considered an exclusively cardiac expressed ion channel but discovered to also act as a novel innate immune sensor. We report on a young SCN5A variant carrier with recurrent ventricular fibrillation and massive myocardial inflammation whose peculiar clinical course is highly suggestive of such a dual role of SCN5A. (<b>Level of Difficulty: Advanced.</b>).","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-22T22:03:03.183Z","creation":"2025-04-06T03:57:31.543Z"},"accession":"S-EPMC8897185","cross_references":{"pubmed":["35257103"],"doi":["10.1016/j.jaccas.2022.01.016"]}}