biostudies-literatureUnknown4(5)Poller WSCN5A was considered an exclusively cardiac expressed ion channel but discovered to also act as a novel innate immune sensor. We report on a young SCN5A variant carrier with recurrent ventricular fibrillation and massive myocardial inflammation whose peculiar clinical course is highly suggestive of such a dual role of SCN5A. (<b>Level of Difficulty: Advanced.</b>).JACC. Case reports280-286https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897185biostudies-literatureMissense Variant E1295K of Sodium Channel SCN5A Associated With Recurrent Ventricular Fibrillation and Myocardial Inflammation.PMC8897185Escher FAttanasio PMeder BHaas JSkurk CSchultheiss HPPoller WHaghikia AHeidecker BKlaassen SfalseMissense Variant E1295K of Sodium Channel SCN5A Associated With Recurrent Ventricular Fibrillation and Myocardial Inflammation.SCN5A was considered an exclusively cardiac expressed ion channel but discovered to also act as a novel innate immune sensor. We report on a young SCN5A variant carrier with recurrent ventricular fibrillation and massive myocardial inflammation whose peculiar clinical course is highly suggestive of such a dual role of SCN5A. (<b>Level of Difficulty: Advanced.</b>).2022-01-01T00:00:00Z2022 Mar2025-04-22T22:03:03.183Z2025-04-06T03:57:31.543ZS-EPMC88971853525710310.1016/j.jaccas.2022.01.016