{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Kuai X"],"pubmed_abstract":["Tumor-targeted immunotherapy is a remarkable breakthrough, offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity. However, existing platforms suffer from low efficacy, inability to induce strong immunogenic cell death (ICD), and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones. Here, an innovative platform, perfluorooctyl bromide (PFOB) nanoemulsions holding MnO<sub>2</sub> nanoparticles (MBP), was developed to orchestrate cancer immunotherapy, serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD. By simultaneously depleting the GSH and eliciting the ICD effect <i>via</i> high-intensity focused ultrasound (HIFU) therapy, the MBP nanomedicine can regulate the tumor i"],"journal":["Acta pharmaceutica Sinica. B"],"pagination":["967-981"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897201"],"repository":["biostudies-literature"],"pubmed_title":["Perfluorooctyl bromide nanoemulsions holding MnO<sub>2</sub> nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death."],"pmcid":["PMC8897201"],"pubmed_authors":["Geng D","Kuai X","Zhu Y","Wang S","Lu Y","Yin B","Luo Y","Pang Z","Lin L","Ye X","Yuan Z"],"additional_accession":[]},"is_claimable":false,"name":"Perfluorooctyl bromide nanoemulsions holding MnO<sub>2</sub> nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death.","description":"Tumor-targeted immunotherapy is a remarkable breakthrough, offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity. However, existing platforms suffer from low efficacy, inability to induce strong immunogenic cell death (ICD), and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones. Here, an innovative platform, perfluorooctyl bromide (PFOB) nanoemulsions holding MnO<sub>2</sub> nanoparticles (MBP), was developed to orchestrate cancer immunotherapy, serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD. By simultaneously depleting the GSH and eliciting the ICD effect <i>via</i> high-intensity focused ultrasound (HIFU) therapy, the MBP nanomedicine can regulate the tumor i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T19:57:37.658Z","creation":"2025-04-04T19:57:37.658Z"},"accession":"S-EPMC8897201","cross_references":{"pubmed":["35256958"],"doi":["10.1016/j.apsb.2021.07.025"]}}