biostudies-literatureUnknown12(2)Kuai XTumor-targeted immunotherapy is a remarkable breakthrough, offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity. However, existing platforms suffer from low efficacy, inability to induce strong immunogenic cell death (ICD), and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones. Here, an innovative platform, perfluorooctyl bromide (PFOB) nanoemulsions holding MnO₂ nanoparticles (MBP), was developed to orchestrate cancer immunotherapy, serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD. By simultaneously depleting the GSH and eliciting the ICD effect <i>via</i> high-intensity focused ultrasound (HIFU) therapy, the MBP nanomedicine can regulate the tumor iActa pharmaceutica Sinica. B967-981https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897201biostudies-literaturePerfluorooctyl bromide nanoemulsions holding MnO₂ nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death.PMC8897201Geng DKuai XZhu YWang SLu YYin BLuo YPang ZLin LYe XYuan ZfalsePerfluorooctyl bromide nanoemulsions holding MnO₂ nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death.Tumor-targeted immunotherapy is a remarkable breakthrough, offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity. However, existing platforms suffer from low efficacy, inability to induce strong immunogenic cell death (ICD), and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones. Here, an innovative platform, perfluorooctyl bromide (PFOB) nanoemulsions holding MnO₂ nanoparticles (MBP), was developed to orchestrate cancer immunotherapy, serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD. By simultaneously depleting the GSH and eliciting the ICD effect <i>via</i> high-intensity focused ultrasound (HIFU) therapy, the MBP nanomedicine can regulate the tumor i2022-01-01T00:00:00Z2022 Feb2025-04-04T19:57:37.658Z2025-04-04T19:57:37.658ZS-EPMC88972013525695810.1016/j.apsb.2021.07.025