{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["181(3)"],"submitter":["Hagedoorn NN"],"funding":["Horizon 2020 Framework Programme"],"pubmed_abstract":["An impaired immune response could play a role in the acquisition of secondary infections in critically ill children. Human leukocyte antigen-DR expression on monocytes (mHLA-DR) has been proposed as marker to detect immunosuppression, but its potential to predict secondary infections in critically ill children is unclear. We aimed to assess the association between mHLA-DR expression at several timepoints and the change of mHLA-DR expression over time with the acquisition of secondary infections in critically ill children. In this prospective observational study, children < 18 years with fever and/or suspected infection (community-acquired or hospital-acquired) were included at a paediatric intensive care unit in the Netherlands. mHLA-DR expression was determined by flow cytometry on day 1,"],"journal":["European journal of pediatrics"],"pagination":["1133-1142"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897323"],"repository":["biostudies-literature"],"pubmed_title":["Association of monocyte HLA-DR expression over time with secondary infection in critically ill children: a prospective observational study."],"pmcid":["PMC8897323"],"pubmed_authors":["Hagedoorn NN","Verbruggen S","Vermont C","Dik WA","Driessen G","Kolukirik P","Nieboer D","Nagtzaam NMA","Joosten KF","Moll H"],"additional_accession":[]},"is_claimable":false,"name":"Association of monocyte HLA-DR expression over time with secondary infection in critically ill children: a prospective observational study.","description":"An impaired immune response could play a role in the acquisition of secondary infections in critically ill children. Human leukocyte antigen-DR expression on monocytes (mHLA-DR) has been proposed as marker to detect immunosuppression, but its potential to predict secondary infections in critically ill children is unclear. We aimed to assess the association between mHLA-DR expression at several timepoints and the change of mHLA-DR expression over time with the acquisition of secondary infections in critically ill children. In this prospective observational study, children < 18 years with fever and/or suspected infection (community-acquired or hospital-acquired) were included at a paediatric intensive care unit in the Netherlands. mHLA-DR expression was determined by flow cytometry on day 1,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-22T03:56:01.704Z","creation":"2025-04-05T20:49:11.429Z"},"accession":"S-EPMC8897323","cross_references":{"pubmed":["34755207"],"doi":["10.1007/s00431-021-04313-7"]}}