{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(3)"],"submitter":["Liu P"],"pubmed_abstract":["Increased glycolysis is a hallmark of tumor, which can provide tumor cells with energy and building blocks to promote cell proliferation. Recent studies have shown that not only the expression of glycolytic genes but also their subcellular localization undergoes a variety of changes to promote development of different types of tumors. In this study, we performed a comprehensive analysis of glycolysis and gluconeogenesis genes based on data from TCGA to identify those with significant tumor-promoting potential across 14 types of tumors. This analysis not only confirms genes that are known to be involved in tumorigenesis, but also reveals a significant correlation of triosephosphate isomerase 1 (TPI1) with poor prognosis, especially in lung adenocarcinoma (LUAD). TPI1 is a glycolytic enzyme "],"journal":["Cell death & disease"],"pagination":["205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897412"],"repository":["biostudies-literature"],"pubmed_title":["Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance."],"pmcid":["PMC8897412"],"pubmed_authors":["Xiong Y","Feng X","Zhang JY","Liu P","Gao Y","Zhang L","Zheng YM","Yuan HX","Ai YJ","Sun SJ","Sun YP","Lin M"],"additional_accession":[]},"is_claimable":false,"name":"Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance.","description":"Increased glycolysis is a hallmark of tumor, which can provide tumor cells with energy and building blocks to promote cell proliferation. Recent studies have shown that not only the expression of glycolytic genes but also their subcellular localization undergoes a variety of changes to promote development of different types of tumors. In this study, we performed a comprehensive analysis of glycolysis and gluconeogenesis genes based on data from TCGA to identify those with significant tumor-promoting potential across 14 types of tumors. This analysis not only confirms genes that are known to be involved in tumorigenesis, but also reveals a significant correlation of triosephosphate isomerase 1 (TPI1) with poor prognosis, especially in lung adenocarcinoma (LUAD). TPI1 is a glycolytic enzyme ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T04:41:14.171Z","creation":"2025-04-26T04:41:14.171Z"},"accession":"S-EPMC8897412","cross_references":{"pubmed":["35246510"],"doi":["10.1038/s41419-022-04655-6"]}}