{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Patel A"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","NIGMS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering"],"pagination":["1185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897416"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Asymmetric signaling and organization in the stem-cell niche determine stem-cell fates. Here, we investigate the basis of asymmetric signaling and stem-cell organization using the Drosophila wing-disc that creates an adult muscle progenitor (AMP) niche. We show that AMPs extend polarized cytonemes to contact the disc epithelial junctions and adhere themselves to the disc/niche. Niche-adhering cytonemes localize FGF-receptor to selectively adhere to the FGF-producing disc and receive FGFs in a contact-dependent manner. Activation of FGF signaling in AMPs, in turn, reinforces disc-specific cytoneme polarity/adhesion, which maintains their disc-proximal positions. Loss of cytoneme-mediated adhesion promotes AMPs to lose niche occupancy and FGF signaling, occupy a disc-distal position, and acq"],"journal":["Nature communications"],"pubmed_title":["Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche."],"pmcid":["PMC8897416"],"funding_grant_id":["Intramural","R35GM124878-03S1","R35GM124878","T32 GM080201","R35 GM124878"],"pubmed_authors":["Patel A","Shroff H","Roy S","Han X","Maugel T","Su Y","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche.","description":"Asymmetric signaling and organization in the stem-cell niche determine stem-cell fates. Here, we investigate the basis of asymmetric signaling and stem-cell organization using the Drosophila wing-disc that creates an adult muscle progenitor (AMP) niche. We show that AMPs extend polarized cytonemes to contact the disc epithelial junctions and adhere themselves to the disc/niche. Niche-adhering cytonemes localize FGF-receptor to selectively adhere to the FGF-producing disc and receive FGFs in a contact-dependent manner. Activation of FGF signaling in AMPs, in turn, reinforces disc-specific cytoneme polarity/adhesion, which maintains their disc-proximal positions. Loss of cytoneme-mediated adhesion promotes AMPs to lose niche occupancy and FGF signaling, occupy a disc-distal position, and acq","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T04:05:01.25Z","creation":"2025-04-06T10:57:53.738Z"},"accession":"S-EPMC8897416","cross_references":{"pubmed":["35246530"],"doi":["10.1038/s41467-022-28587-z"]}}