{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanchez-Pino MD"],"funding":["NIDDK NIH HHS","National Cancer Institute","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["103910"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897585"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77"],"pubmed_abstract":["<h4>Background</h4>Low-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role in the low-grade chronic inflammation associated with obesity. Here we explored their role in obesity, determined their gene signatures, and assessed the effect of bariatric surgery.<h4>Methods</h4>We compared the number, function, and gene expression profiles of circulating LDN in morbidly obese patients (MOP, n=27; body mass index (BMI) > 40 Kg/m<sup>2</sup>) and normal-weight controls (NWC, n=20; BMI < 25 Kg/m<sup>2</sup>) in a case-control study. Additionally, in a prospective longitudinal study, we measured changes in the frequency of LDN after bariatric surgery (n=36) and tested for associations with metabolic and inflammatory parameters.<h4>Findings</h4>LDN and in"],"journal":["EBioMedicine"],"pubmed_title":["Increased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies."],"pmcid":["PMC8897585"],"funding_grant_id":["P20 CA233374","P30 DK072476","P20CA233374-A","P30 GM114732","U54 GM104940","5P30GM114732-02","R01 CA233512","R21 CA210237"],"pubmed_authors":["Miele L","Chapple AG","Liu J","Wyczechowska D","Al-Khami AA","Richardson WS","Sanchez-Pino MD","Baiamonte LB","Davis M","DeArmitt R","Gorham JK","Zabaleta J","Puttalingaiah RT","Zheng L","Rodriguez PC","Ponder M","Kim Y","Ochoa AC","Martini R","Wooldridge JB","Garai J"],"additional_accession":[]},"is_claimable":false,"name":"Increased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies.","description":"<h4>Background</h4>Low-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role in the low-grade chronic inflammation associated with obesity. Here we explored their role in obesity, determined their gene signatures, and assessed the effect of bariatric surgery.<h4>Methods</h4>We compared the number, function, and gene expression profiles of circulating LDN in morbidly obese patients (MOP, n=27; body mass index (BMI) > 40 Kg/m<sup>2</sup>) and normal-weight controls (NWC, n=20; BMI < 25 Kg/m<sup>2</sup>) in a case-control study. Additionally, in a prospective longitudinal study, we measured changes in the frequency of LDN after bariatric surgery (n=36) and tested for associations with metabolic and inflammatory parameters.<h4>Findings</h4>LDN and in","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-01T02:08:05.357Z","creation":"2025-04-05T09:49:27.473Z"},"accession":"S-EPMC8897585","cross_references":{"pubmed":["35248994"],"doi":["10.1016/j.ebiom.2022.103910"]}}