biostudies-literatureSanchez-Pino MDNIDDK NIH HHSNational Cancer InstituteNCI NIH HHSNational Institutes of HealthNIGMS NIH HHS103910https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897585biostudies-literatureUnknown77<h4>Background</h4>Low-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role in the low-grade chronic inflammation associated with obesity. Here we explored their role in obesity, determined their gene signatures, and assessed the effect of bariatric surgery.<h4>Methods</h4>We compared the number, function, and gene expression profiles of circulating LDN in morbidly obese patients (MOP, n=27; body mass index (BMI) > 40 Kg/m²) and normal-weight controls (NWC, n=20; BMI < 25 Kg/m²) in a case-control study. Additionally, in a prospective longitudinal study, we measured changes in the frequency of LDN after bariatric surgery (n=36) and tested for associations with metabolic and inflammatory parameters.<h4>Findings</h4>LDN and inEBioMedicineIncreased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies.PMC8897585P20 CA233374P30 DK072476P20CA233374-AP30 GM114732U54 GM1049405P30GM114732-02R01 CA233512R21 CA210237Miele LChapple AGLiu JWyczechowska DAl-Khami AARichardson WSSanchez-Pino MDBaiamonte LBDavis MDeArmitt RGorham JKZabaleta JPuttalingaiah RTZheng LRodriguez PCPonder MKim YOchoa ACMartini RWooldridge JBGarai JfalseIncreased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies.<h4>Background</h4>Low-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role in the low-grade chronic inflammation associated with obesity. Here we explored their role in obesity, determined their gene signatures, and assessed the effect of bariatric surgery.<h4>Methods</h4>We compared the number, function, and gene expression profiles of circulating LDN in morbidly obese patients (MOP, n=27; body mass index (BMI) > 40 Kg/m²) and normal-weight controls (NWC, n=20; BMI < 25 Kg/m²) in a case-control study. Additionally, in a prospective longitudinal study, we measured changes in the frequency of LDN after bariatric surgery (n=36) and tested for associations with metabolic and inflammatory parameters.<h4>Findings</h4>LDN and in2022-01-01T00:00:00Z2022 Mar2026-06-01T02:08:05.357Z2025-04-05T09:49:27.473ZS-EPMC88975853524899410.1016/j.ebiom.2022.103910