biostudies-literatureZhao LMWest China Hospital, Sichuan UniversityNational Natural Science Foundation of ChinaSichuan UniversityNational Key Research and Development Program of China206-218https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897693biostudies-literatureUnknown14Approximately 25% of patients with congenital heart disease require implantation of patches to repair. However, most of the currently available patches are made of inert materials with unmatched electrical conductivity and mechanical properties, which may lead to an increased risk for arrhythmia and heart failure. In this study, we have developed a novel Polyurethane/Small intestinal submucosa patch (PSP) with mechanical and electrical properties similar to those of the native myocardial tissue, and assessed its feasibility for the reconstruction of right ventricular outflow tract. A right ventricular outflow tract reconstruction model was constructed in 40 rabbits. Compared with commercially available bovine pericardium patch, the PSP patch has shown better histocompatibility and biodegraBioactive materialsPromotion of right ventricular outflow tract reconstruction using a novel cardiac patch incorporated with hypoxia-pretreated urine-derived stem cells.PMC8897693ZYJC18002317710652017YFC1104702Zhang XZWang RXie HQLiang YZhao LMZhang QYSong YTZhang WQLin KWang LLei XXfalsePromotion of right ventricular outflow tract reconstruction using a novel cardiac patch incorporated with hypoxia-pretreated urine-derived stem cells.Approximately 25% of patients with congenital heart disease require implantation of patches to repair. However, most of the currently available patches are made of inert materials with unmatched electrical conductivity and mechanical properties, which may lead to an increased risk for arrhythmia and heart failure. In this study, we have developed a novel Polyurethane/Small intestinal submucosa patch (PSP) with mechanical and electrical properties similar to those of the native myocardial tissue, and assessed its feasibility for the reconstruction of right ventricular outflow tract. A right ventricular outflow tract reconstruction model was constructed in 40 rabbits. Compared with commercially available bovine pericardium patch, the PSP patch has shown better histocompatibility and biodegra2022-01-01T00:00:00Z2022 Aug2025-04-19T12:54:13.121Z2025-04-19T12:54:13.121ZS-EPMC88976933531035610.1016/j.bioactmat.2021.11.021