biostudies-literatureHolmen Olofsson GElse og Mogens Wedell Wedellsborgs FondFabrikant Einar Willumsens MindelegatKaren A. Tolstrups FondDr.phil Ragna Rask-Nielsens FondAxel Muusfeldts FondSundhedsstyrelsenFamilien Erichsens MindefondNeye FondAase og Ejnar Danielsens Fond246https://www.ebi.ac.uk/biostudies/studies/S-EPMC8897734biostudies-literatureUnknown22(1)<h4>Background</h4>The increasing role of exercise training in cancer care is built on evidence that exercise can reduce side effects of treatment, improve physical functioning and quality of life. We and others have shown in mouse tumor models, that exercise leads to an adrenalin-mediated increased influx of T and NK cells into the tumor, altering the tumor microenvironment (TME) and leading to reduced tumor growth. These data suggest that exercise could improve immune responses against cancer cells by increase immune cell infiltration to the tumor and potentially having an impact on disease progression. Additionally, there are data to suggest that infiltration of T and NK cells into the TME is correlates with response to immune checkpoint inhibitors in patients. We have therefore initiatBMC cancerHigh Intensity Aerobic exercise training and Immune cell Mobilization in patients with lung cancer (HI AIM)-a randomized controlled trial.PMC88977342020-04122017-677300.106-0141526505-0400-5019-10-02739-21-205-0400-18Horsted CBHolmen Olofsson GNielsen DLLorentzen THeide-Ottosen LOlsen APChristiansen ABThor Straten PPersson GFEngell-Noerregaard LMikkelsen MKRagle AMVinther APedersen CMSfalseHigh Intensity Aerobic exercise training and Immune cell Mobilization in patients with lung cancer (HI AIM)-a randomized controlled trial.<h4>Background</h4>The increasing role of exercise training in cancer care is built on evidence that exercise can reduce side effects of treatment, improve physical functioning and quality of life. We and others have shown in mouse tumor models, that exercise leads to an adrenalin-mediated increased influx of T and NK cells into the tumor, altering the tumor microenvironment (TME) and leading to reduced tumor growth. These data suggest that exercise could improve immune responses against cancer cells by increase immune cell infiltration to the tumor and potentially having an impact on disease progression. Additionally, there are data to suggest that infiltration of T and NK cells into the TME is correlates with response to immune checkpoint inhibitors in patients. We have therefore initiat2022-01-01T00:00:00Z2022 Mar2025-05-18T12:35:09.25Z2025-04-06T12:04:46.617ZS-EPMC88977343524799410.1186/s12885-022-09349-y