{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(4)"],"submitter":["Chen K"],"pubmed_abstract":["Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our study. The microRNA miR-497-5p targets R-spondin 2 (RSPO2) only when it is present. RSPO2 silencing has the same effect on GBM cells as miR-497-5p silencing, as demonstrated before. Additional mechanistic investigations have shown that miR-497-5p suppresses the Wnt/β-catenin signaling pathway by targeting RSPO2 to reduce cell proliferation, migration, and invasion. A negative correlation was discovered between MiR-497-5p and RSPO2 in 37 of the GBM tumors studied. MiR-497-5p-RSPO2 axis controls Wnt"],"journal":["Journal of Cancer"],"pagination":["1241-1251"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8899375"],"repository":["biostudies-literature"],"pubmed_title":["miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma."],"pmcid":["PMC8899375"],"pubmed_authors":["Zhou MY","Chen K","Zong QB","Chen QF","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma.","description":"Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our study. The microRNA miR-497-5p targets R-spondin 2 (RSPO2) only when it is present. RSPO2 silencing has the same effect on GBM cells as miR-497-5p silencing, as demonstrated before. Additional mechanistic investigations have shown that miR-497-5p suppresses the Wnt/β-catenin signaling pathway by targeting RSPO2 to reduce cell proliferation, migration, and invasion. A negative correlation was discovered between MiR-497-5p and RSPO2 in 37 of the GBM tumors studied. MiR-497-5p-RSPO2 axis controls Wnt","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-18T08:52:04.142Z","creation":"2025-04-04T14:58:41.382Z"},"accession":"S-EPMC8899375","cross_references":{"pubmed":["35281864"],"doi":["10.7150/jca.62652"]}}