{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Luo YY"],"pubmed_abstract":["Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, and its incidence is still high in China. This study aimed to investigate the circular RNAs (circRNAs) involved in the development of HCC and elucidate the mechanism. RNA sequencing found 72 downregulated circRNAs and 88 upregulated circRNAs in human HCC tissues, including hsa_circ_0098181, hsa_circ_0072309, hsa_circ_0000831, and hsa_circ_0000231. The reduction of hsa_circ_0098181 was confirmed in eight paired human HCC tissues, hepatoma cell lines, and CCL4/DEN-induced mouse HCC models by RT-qPCR. The FISH assay revealed that hsa_circ_0098181 is mainly located in the cytoplasm of hepatocytes in the paratumor tissues. Further log-rank analysis performed in 91 HCC patients demonstrated that low expression "],"journal":["Frontiers in pharmacology"],"pagination":["819735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8899401"],"repository":["biostudies-literature"],"pubmed_title":["Hsa_Circ_0098181 Suppresses Hepatocellular Carcinoma by Sponging miR-18a-3p and Targeting PPARA."],"pmcid":["PMC8899401"],"pubmed_authors":["Liu Y","Ding CH","Lu YT","Yan FZ","Zhang X","Tao KG","Lin Y","Zeng X","Wu KM","Li BB","Luo YY"],"additional_accession":[]},"is_claimable":false,"name":"Hsa_Circ_0098181 Suppresses Hepatocellular Carcinoma by Sponging miR-18a-3p and Targeting PPARA.","description":"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, and its incidence is still high in China. This study aimed to investigate the circular RNAs (circRNAs) involved in the development of HCC and elucidate the mechanism. RNA sequencing found 72 downregulated circRNAs and 88 upregulated circRNAs in human HCC tissues, including hsa_circ_0098181, hsa_circ_0072309, hsa_circ_0000831, and hsa_circ_0000231. The reduction of hsa_circ_0098181 was confirmed in eight paired human HCC tissues, hepatoma cell lines, and CCL4/DEN-induced mouse HCC models by RT-qPCR. The FISH assay revealed that hsa_circ_0098181 is mainly located in the cytoplasm of hepatocytes in the paratumor tissues. Further log-rank analysis performed in 91 HCC patients demonstrated that low expression ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T14:58:24.045Z","creation":"2025-04-04T14:58:24.045Z"},"accession":"S-EPMC8899401","cross_references":{"pubmed":["35264957"],"doi":["10.3389/fphar.2022.819735"]}}