{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fan C"],"funding":["National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers","Fundamental Research Fund of Shandong University","Natural Science Foundation of Shandong Province","National Natural Science Foundation of China"],"pagination":["1300-1314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8899528"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(3)"],"pubmed_abstract":["Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for maintaining brain development and function in many neurological diseases. However, the neural mechanisms underlying neurogenesis in depression remain unclear. Here, we show that microglia transfer a microglia-enriched microRNA, miR-146a-5p, via secreting exosomes to inhibit neurogenesis in depression. Overexpression of miR-146a-5p in hippocampal DG suppresses neurogenesis and spontaneous discharge of excitatory neurons by directly targeting Krüppel-like factor 4 (KLF4). Downregulation of miR-146a-5p expression ameliorates adult neurogenesis deficits in DG regions and depression-like behaviors in rats. Intriguingly, circular RNA ANKS1B acts as a miRNA sequester for miR-146a-5p to mediate post-transcriptional re"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pubmed_title":["Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression."],"pmcid":["PMC8899528"],"funding_grant_id":["ZR2020ZD25","2018JC008","82071513","NSFC81873796"],"pubmed_authors":["Lan T","Yu SY","Li Y","Long Y","Wang W","Fan C"],"additional_accession":[]},"is_claimable":false,"name":"Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression.","description":"Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for maintaining brain development and function in many neurological diseases. However, the neural mechanisms underlying neurogenesis in depression remain unclear. Here, we show that microglia transfer a microglia-enriched microRNA, miR-146a-5p, via secreting exosomes to inhibit neurogenesis in depression. Overexpression of miR-146a-5p in hippocampal DG suppresses neurogenesis and spontaneous discharge of excitatory neurons by directly targeting Krüppel-like factor 4 (KLF4). Downregulation of miR-146a-5p expression ameliorates adult neurogenesis deficits in DG regions and depression-like behaviors in rats. Intriguingly, circular RNA ANKS1B acts as a miRNA sequester for miR-146a-5p to mediate post-transcriptional re","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T10:23:08.449Z","creation":"2025-04-06T13:18:28.79Z"},"accession":"S-EPMC8899528","cross_references":{"pubmed":["34768001"],"doi":["10.1016/j.ymthe.2021.11.006"]}}