{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(3)"],"submitter":["Huang S"],"pubmed_abstract":["Immunosuppression in response to severe sepsis remains a serious human health concern. Evidence of sepsis-induced immunosuppression includes impaired T lymphocyte function, T lymphocyte depletion or exhaustion, increased susceptibility to opportunistic nosocomial infection, and imbalanced cytokine secretion. CD4 T cells play a critical role in cellular and humoral immune responses during sepsis. Here, using an RNA sequencing assay, we found that the expression of T cell-containing immunoglobulin and mucin domain-3 (Tim-3) on CD4 T cells in sepsis-induced immunosuppression patients was significantly elevated. Furthermore, the percentage of Tim-3<sup>+</sup> CD4 T cells from sepsis patients was correlated with the mortality of sepsis-induced immunosuppression. Conditional deletion of Tim-3 i"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pagination":["1227-1238"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8899604"],"repository":["biostudies-literature"],"pubmed_title":["Tim-3 regulates sepsis-induced immunosuppression by inhibiting the NF-κB signaling pathway in CD4 T cells."],"pmcid":["PMC8899604"],"pubmed_authors":["Qiu J","Jiang J","Huang S","Wang Q","Zhang J","Gan L","Zeng L","Zhang H","Deng J","Liu D","Qu G","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"Tim-3 regulates sepsis-induced immunosuppression by inhibiting the NF-κB signaling pathway in CD4 T cells.","description":"Immunosuppression in response to severe sepsis remains a serious human health concern. Evidence of sepsis-induced immunosuppression includes impaired T lymphocyte function, T lymphocyte depletion or exhaustion, increased susceptibility to opportunistic nosocomial infection, and imbalanced cytokine secretion. CD4 T cells play a critical role in cellular and humoral immune responses during sepsis. Here, using an RNA sequencing assay, we found that the expression of T cell-containing immunoglobulin and mucin domain-3 (Tim-3) on CD4 T cells in sepsis-induced immunosuppression patients was significantly elevated. Furthermore, the percentage of Tim-3<sup>+</sup> CD4 T cells from sepsis patients was correlated with the mortality of sepsis-induced immunosuppression. Conditional deletion of Tim-3 i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-28T08:07:38.819Z","creation":"2025-04-25T17:05:38.374Z"},"accession":"S-EPMC8899604","cross_references":{"pubmed":["34933101"],"doi":["10.1016/j.ymthe.2021.12.013"]}}