biostudies-literatureKaralis JDburroughs wellcome fundmark foundation for cancer researchdedman family scholarshipNCI NIH HHSnational cancer institute116https://www.ebi.ac.uk/biostudies/studies/S-EPMC8900296biostudies-literatureUnknown20(1)<h4>Background</h4>Lenvatinib is a multitargeted tyrosine kinase inhibitor that is being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficacy of lenvatinib monotherapy. Patient-derived xenografts (PDX) are established by engrafting human tumors into immunodeficient mice. The generation of PDXs may be hampered by growth of lymphomas. In this study, we compared the use of mice with different degrees of immunodeficiency to establish PDXs from a diverse cohort of Western gastric cancer patients. We then tested the efficacy of lenvatinib in this system.<h4>Methods</h4>PDXs were established by implanting gastric cancer tissue into NOD.Cg-Prkdc^scidIl2rg^tm1Wjl/SzJ (NSG) or Foxn1<sup>nu</suJournal of translational medicineLenvatinib inhibits the growth of gastric cancer patient-derived xenografts generated from a heterogeneous population.PMC8900296R01 CA251928K08 CA2226111018897P30 CA142543Hammer STGPolanco PMSuarez JCastro-Dubon ECReznik SIMansour JCNassour IZhu HWang SCXiao SHong CZhu MAgrawal DJu MRHwang THKaralis JDZeh HJPorembka MRYoon LYYopp ACfalseLenvatinib inhibits the growth of gastric cancer patient-derived xenografts generated from a heterogeneous population.<h4>Background</h4>Lenvatinib is a multitargeted tyrosine kinase inhibitor that is being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficacy of lenvatinib monotherapy. Patient-derived xenografts (PDX) are established by engrafting human tumors into immunodeficient mice. The generation of PDXs may be hampered by growth of lymphomas. In this study, we compared the use of mice with different degrees of immunodeficiency to establish PDXs from a diverse cohort of Western gastric cancer patients. We then tested the efficacy of lenvatinib in this system.<h4>Methods</h4>PDXs were established by implanting gastric cancer tissue into NOD.Cg-Prkdc^scidIl2rg^tm1Wjl/SzJ (NSG) or Foxn1<sup>nu</su2022-01-01T00:00:00Z2022 Mar2026-04-12T15:03:19.673Z2025-04-04T13:21:59.39ZS-EPMC89002963525594010.1186/s12967-022-03317-7