biostudies-literatureWorldWide Antimalarial Resistance Network Falciparum Haematology Study GroupMedical Research CouncilExxonMobil FoundationNational Health and Medical Research CouncilBill and Melinda Gates FoundationWellcome Trust85https://www.ebi.ac.uk/biostudies/studies/S-EPMC8900374biostudies-literatureUnknown20(1)<h4>Background</h4>Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia.<h4>Methods</h4>Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. MultivaBMC medicineHaematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data.PMC8900374MC_UP_A900_111911947021104975200909Bukirwa HNji AMAdjei GOAdjuik MEspie EMansoor RGonzalez RAshurst HBoulton CMenard DGenton BWorldWide Antimalarial Resistance Network Falciparum Haematology Study GroupStrub-Wourgaft NNoedl HRamharter MMenan HKarema CTinto HFaucher JFPrice RNSirima SBMartensson ASyafruddin DBassat QBrasseur PStaedke SGD'Alessandro UAchan JDuparc SToure OATemu EAValentini GKiechel JRGilayeneh JThwing JIIshengoma DRoper CDesai MEtard JFGuerin PJMbacham WBjorkman AHodel EMJuma ELalloo DGAshley EAArinaitwe ESimpson JAStarzengruber Pvan Vugt MLee SJAbuaku BWard SAFalade CKamya MRPremji ZHumphreys GSCot MGreenwood BUrsing JWoodrow CJSutanto IPlucinski MKofoed PESome FABell DJSmithuis FMAsih PBSOwusu-Agyei SRosenthal PJSwarthout TDStepniewska KAlemayehu BHBakyaita NAdam IFukuda MGaye OMayxay MBarennes HYeka AMuller OGrais RFKager PAGhulam Rahim AKoram KMockenhaupt FNikiema FBaudin EDjimde AANewton PNvon Seidlein LDavis TMELaman MOuedraogo JBHatz COjurongbe OTjitra EPareek AOgutu BRCarrara VIWere VDouglas NMFiller SNosten FNahum ANdiaye JLPenali LKPiola PYavo WDorsey GGrandesso FSalman SValea IBousema TRombo LAllan RKachur SPMcGready RBurrow RAllen ENDas SLell BRichmond CLKazienga ADrakeley CJFogg CZongo INgasala BESame-Ekobo ABethell DKayentao KSibley CMaiga AWAnvikar ARDondorp AMBarnes KIKamugisha ECommons RJBasco LTalisuna AOTaylor WRHwang JGrivoyannis AOsorio LTran THDas DKremsner PGMoore BRWhite NJfalseHaematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data.<h4>Background</h4>Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia.<h4>Methods</h4>Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multiva2022-01-01T00:00:00Z2022 Mar2025-04-04T19:58:10.051Z2025-04-04T19:58:10.051ZS-EPMC89003743524954610.1186/s12916-022-02265-9