{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun N"],"funding":["NIBIB NIH HHS","Collaborative Innovation Center of Suzhou Nano Science and Technology","NCI NIH HHS","National Institutes of Health"],"pagination":["113854"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8900541"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["199"],"pubmed_abstract":["Circulating tumor cell (CTC) clusters are present in cancer patients with severe metastasis, resulting in poor clinical outcomes. However, CTC clusters have not been studied as extensively as single CTCs, and the clinical utility of CTC clusters remains largely unknown. In this study, we aim sought to explore the feasibility of NanoVelcro Chips to simultaneously detect both single CTCs and CTC clusters with negligible perturbation to their intrinsic properties in neuroendocrine tumors (NETs). We discovered frequent CTC clusters in patients with advanced NETs and examined their potential roles, together with single NET CTCs, as novel biomarkers of patient response following peptide receptor radionuclide therapy (PRRT). We observed dynamic changes in both total NET CTCs and NET CTC cluster c"],"journal":["Biosensors & bioelectronics"],"pubmed_title":["Discovery and characterization of circulating tumor cell clusters in neuroendocrine tumor patients using nanosubstrate-embedded microchips."],"pmcid":["PMC8900541"],"funding_grant_id":["R01 CA253651","R21 CA240887","R21 CA235340","U01 CA198900","R01 CA255727","U01 EB026421","R01 CA246304"],"pubmed_authors":["Liu H","Huang YW","Redublo P","Zhang D","Zhu Y","Miao H","Wang J","Tseng HR","Bergsland EK","Liu W","Sun N","Liang IY","Liang L","Zhang C","Wang JJ","Heaney AP","Lee YT","Chou SJ","Allen-Auerbach MS","Teng PC","Posadas EM","Zhang TX","Zhang RY","Pei R","Smalley M","Hope TA","Yang Y","Zhang Z","Yang P","Weiss PS","Huai K","Donahue T","Hecht JR"],"additional_accession":[]},"is_claimable":false,"name":"Discovery and characterization of circulating tumor cell clusters in neuroendocrine tumor patients using nanosubstrate-embedded microchips.","description":"Circulating tumor cell (CTC) clusters are present in cancer patients with severe metastasis, resulting in poor clinical outcomes. However, CTC clusters have not been studied as extensively as single CTCs, and the clinical utility of CTC clusters remains largely unknown. In this study, we aim sought to explore the feasibility of NanoVelcro Chips to simultaneously detect both single CTCs and CTC clusters with negligible perturbation to their intrinsic properties in neuroendocrine tumors (NETs). We discovered frequent CTC clusters in patients with advanced NETs and examined their potential roles, together with single NET CTCs, as novel biomarkers of patient response following peptide receptor radionuclide therapy (PRRT). We observed dynamic changes in both total NET CTCs and NET CTC cluster c","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T23:13:13.068Z","creation":"2025-04-19T23:13:13.068Z"},"accession":"S-EPMC8900541","cross_references":{"pubmed":["34896918"],"doi":["10.1016/j.bios.2021.113854"]}}