{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(2)"],"submitter":["Brouns SLN"],"pubmed_abstract":["<h4>Background</h4>Low plasma levels of protein C or protein S are associated with venous thromboembolism rather than myocardial infarction. The high coagulant activity in patients with thrombophilia with a (familial) defect in protein C or S is explained by defective protein C activation, involving thrombomodulin and protein S. This causes increased plasmatic thrombin generation.<h4>Objective</h4>Assess the role of platelets in the thrombus- and fibrin-forming potential in patients with familial protein C or protein S deficiency under high-shear flow conditions.<h4>Patients/methods</h4>Whole blood from 23 patients and 15 control subjects was perfused over six glycoprotein VI-dependent microspot surfaces. By real-time multicolor microscopic imaging, kinetics of platelet thrombus and fibrin"],"journal":["Research and practice in thrombosis and haemostasis"],"pagination":["e12678"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8900581"],"repository":["biostudies-literature"],"pubmed_title":["Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow."],"pmcid":["PMC8900581"],"pubmed_authors":["van Oerle R","Perrella G","Kuijpers MJE","Spiezia L","van Geffen JP","Simioni P","Tullemans BME","Brouns SLN","Campello E","Spronk HMH","Bulato C","van der Meijden PEJ","Heemskerk JWM"],"additional_accession":[]},"is_claimable":false,"name":"Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow.","description":"<h4>Background</h4>Low plasma levels of protein C or protein S are associated with venous thromboembolism rather than myocardial infarction. The high coagulant activity in patients with thrombophilia with a (familial) defect in protein C or S is explained by defective protein C activation, involving thrombomodulin and protein S. This causes increased plasmatic thrombin generation.<h4>Objective</h4>Assess the role of platelets in the thrombus- and fibrin-forming potential in patients with familial protein C or protein S deficiency under high-shear flow conditions.<h4>Patients/methods</h4>Whole blood from 23 patients and 15 control subjects was perfused over six glycoprotein VI-dependent microspot surfaces. By real-time multicolor microscopic imaging, kinetics of platelet thrombus and fibrin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T14:50:38.458Z","creation":"2025-04-04T14:50:38.458Z"},"accession":"S-EPMC8900581","cross_references":{"pubmed":["35284776"],"doi":["10.1002/rth2.12678"]}}