{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hanlon P"],"funding":["Versus Arthritis","Medical Research Council","Wellcome Trust"],"pagination":["e1003931"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8901063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(3)"],"pubmed_abstract":["<h4>Background</h4>Cohorts such as UK Biobank are increasingly used to study multimorbidity; however, there are concerns that lack of representativeness may lead to biased results. This study aims to compare associations between multimorbidity and adverse health outcomes in UK Biobank and a nationally representative sample.<h4>Methods and findings</h4>These are observational analyses of cohorts identified from linked routine healthcare data from UK Biobank participants (n = 211,597 from England, Scotland, and Wales with linked primary care data, age 40 to 70, mean age 56.5 years, 54.6% women, baseline assessment 2006 to 2010) and from the Secure Anonymised Information Linkage (SAIL) databank (n = 852,055 from Wales, age 40 to 70, mean age 54.2, 50.0% women, baseline January 2011). Multimor"],"journal":["PLoS medicine"],"pubmed_title":["Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: A comparison of longitudinal cohort studies."],"pmcid":["PMC8901063"],"funding_grant_id":["21970","MR/S021949/1","201492/Z/16/Z"],"pubmed_authors":["Lewsey J","Jani BD","Mair FS","Nicholl B","McAllister DA","Hanlon P"],"additional_accession":[]},"is_claimable":false,"name":"Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: A comparison of longitudinal cohort studies.","description":"<h4>Background</h4>Cohorts such as UK Biobank are increasingly used to study multimorbidity; however, there are concerns that lack of representativeness may lead to biased results. This study aims to compare associations between multimorbidity and adverse health outcomes in UK Biobank and a nationally representative sample.<h4>Methods and findings</h4>These are observational analyses of cohorts identified from linked routine healthcare data from UK Biobank participants (n = 211,597 from England, Scotland, and Wales with linked primary care data, age 40 to 70, mean age 56.5 years, 54.6% women, baseline assessment 2006 to 2010) and from the Secure Anonymised Information Linkage (SAIL) databank (n = 852,055 from Wales, age 40 to 70, mean age 54.2, 50.0% women, baseline January 2011). Multimor","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-22T22:00:06.713Z","creation":"2025-04-06T03:57:49.295Z"},"accession":"S-EPMC8901063","cross_references":{"pubmed":["35255092"],"doi":["10.1371/journal.pmed.1003931"]}}