{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ren Y"],"funding":["National Natural Science Foundation of China","NCI NIH HHS","NINDS NIH HHS","National Institutes of Health","New York State Stem Cell Science"],"pagination":["70-79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8901260"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(1)"],"pubmed_abstract":["<h4>Background</h4>Despite intense efforts to develop an objective diagnostic test for Parkinson's disease, there is still no consensus on biomarkers that can accurately diagnose the disease.<h4>Objective</h4>Identification of biomarkers for idiopathic Parkinson's disease (PD) may enable accurate diagnosis of the disease. We tried to find molecular and cellular differences in dopaminergic (DA) neurons derived from healthy subjects and idiopathic PD patients with or without rest tremor at onset.<h4>Methods</h4>We measured the expression of genes controlling dopamine synthesis, sequestration, and catabolism as well as the levels of corresponding metabolites and reactive oxygen species in midbrain DA neurons differentiated from induced pluripotent stem cells (iPSCs) of healthy subjects and PD"],"journal":["Movement disorders : official journal of the Movement Disorder Society"],"pubmed_title":["Molecular Features of Parkinson's Disease in Patient-Derived Midbrain Dopaminergic Neurons."],"pmcid":["PMC8901260"],"funding_grant_id":["P30CA016056","C028129","81520108010","P30 CA016056","81771216","R01 NS113763","NS113763"],"pubmed_authors":["Wu J","Feng J","Ren Y","Jiang H","Zhao G","Pu J","Yan Y","Li L","Guttuso TJ","Zhang B"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Features of Parkinson's Disease in Patient-Derived Midbrain Dopaminergic Neurons.","description":"<h4>Background</h4>Despite intense efforts to develop an objective diagnostic test for Parkinson's disease, there is still no consensus on biomarkers that can accurately diagnose the disease.<h4>Objective</h4>Identification of biomarkers for idiopathic Parkinson's disease (PD) may enable accurate diagnosis of the disease. We tried to find molecular and cellular differences in dopaminergic (DA) neurons derived from healthy subjects and idiopathic PD patients with or without rest tremor at onset.<h4>Methods</h4>We measured the expression of genes controlling dopamine synthesis, sequestration, and catabolism as well as the levels of corresponding metabolites and reactive oxygen species in midbrain DA neurons differentiated from induced pluripotent stem cells (iPSCs) of healthy subjects and PD","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-26T00:23:01.949Z","creation":"2025-04-06T09:43:11.149Z"},"accession":"S-EPMC8901260","cross_references":{"pubmed":["34564901"],"doi":["10.1002/mds.28786"]}}