biostudies-literatureUnknown43(1)Zhao JKey research and development plan of Shaanxi province, ChinaThe discipline boosting program of the Xijing Hospital of the Fourth Military Medical University<h4>Background</h4>Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN) through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could reestablish the micro-ecological balance in IgAN, although this has never been attempted before. We explored whether FMT could be efficacious in treating IgAN in two patients with refractory IgAN.<h4>Case presentation</h4>Two Chinese female patients with IgAN failed to achieve clinical remission after receiving several rounds of immunosuppressive therapy and suffered from unbearable adverse effects due to immunosuppressants. Both patients received intensive fresh FMT conducted through transendoscopic enteral tubing (TET) regularly for 6-7 months, and were followed up for a further 6 months. Partial clinical Renal failure928-933https://www.ebi.ac.uk/biostudies/studies/S-EPMC8901287biostudies-literatureAlleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports.PMC8901287Yang XSun SBai MLi RWang YZhao JfalseAlleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports.<h4>Background</h4>Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN) through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could reestablish the micro-ecological balance in IgAN, although this has never been attempted before. We explored whether FMT could be efficacious in treating IgAN in two patients with refractory IgAN.<h4>Case presentation</h4>Two Chinese female patients with IgAN failed to achieve clinical remission after receiving several rounds of immunosuppressive therapy and suffered from unbearable adverse effects due to immunosuppressants. Both patients received intensive fresh FMT conducted through transendoscopic enteral tubing (TET) regularly for 6-7 months, and were followed up for a further 6 months. Partial clinical 2021-01-01T00:00:00Z2021 Dec2025-04-22T22:06:16.491Z2025-04-06T03:55:53.216ZS-EPMC89012873413460510.1080/0886022X.2021.1936038