{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vohra SN"],"funding":["Komen Graduate Training in Disparities Research Grant","UNC Cancer Control Education Program","NCI NIH HHS","University Cancer Research Fund of North Carolina, the Komen Graduate Training in Disparities Research","NIH","NCI NIH","University Cancer Research Fund of North Carolina and Susan G. Komen for the Cure"],"pagination":["561-568"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8901538"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(3)"],"pubmed_abstract":["<h4>Background</h4>Breast cancers in recently postpartum women may have worse outcomes, but studies examining tumor molecular features by pregnancy recency have shown conflicting results.<h4>Methods</h4>This analysis used Carolina Breast Cancer Study data to examine clinical and molecular tumor features among women less than 50 years of age who were recently (≤10 years prior) or remotely (>10 years prior) postpartum, or nulliparous. Prevalence odds ratios (POR) and 95% confidence intervals (CI) were estimated using multivariable models.<h4>Results</h4>Recently postpartum women (N = 618) were more frequently lymph node-positive [POR (95% CI): 1.66 (1.26-2.19)], estrogen receptor (ER)-negative [1.37 (1.02-1.83)], and IHC-based triple negative [1.57 (1.00-2.47)] compared with nulliparous (N ="],"journal":["Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"],"pubmed_title":["Molecular and Clinical Characterization of Postpartum-Associated Breast Cancer in the Carolina Breast Cancer Study Phase I-III, 1993-2013."],"pmcid":["PMC8901538"],"funding_grant_id":["T32CA057726","OGUNC1202","P30CA016086","P50 CA058223","T32 CA057726","P30 CA016086","GTDR16381071","P50-CA58223","P01 CA151135","P01CA151135"],"pubmed_authors":["Sherman ME","Schedin P","Hamilton AM","Troester MA","Walens A","Love MI","Nichols HB","Olshan AF","Vohra SN","Reeder-Hayes KE"],"additional_accession":[]},"is_claimable":false,"name":"Molecular and Clinical Characterization of Postpartum-Associated Breast Cancer in the Carolina Breast Cancer Study Phase I-III, 1993-2013.","description":"<h4>Background</h4>Breast cancers in recently postpartum women may have worse outcomes, but studies examining tumor molecular features by pregnancy recency have shown conflicting results.<h4>Methods</h4>This analysis used Carolina Breast Cancer Study data to examine clinical and molecular tumor features among women less than 50 years of age who were recently (≤10 years prior) or remotely (>10 years prior) postpartum, or nulliparous. Prevalence odds ratios (POR) and 95% confidence intervals (CI) were estimated using multivariable models.<h4>Results</h4>Recently postpartum women (N = 618) were more frequently lymph node-positive [POR (95% CI): 1.66 (1.26-2.19)], estrogen receptor (ER)-negative [1.37 (1.02-1.83)], and IHC-based triple negative [1.57 (1.00-2.47)] compared with nulliparous (N =","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-22T09:59:53.082Z","creation":"2025-04-05T23:24:15.148Z"},"accession":"S-EPMC8901538","cross_references":{"pubmed":["34810211"],"doi":["10.1158/1055-9965.epi-21-0940","10.1158/1055-9965.EPI-21-0940"]}}