{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tykalova T"],"funding":["Ministerstvo Zdravotnictví Ceské Republiky","Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic)"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8901688"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["The effect of dopaminergic medication on speech has rarely been examined in early-stage Parkinson's disease (PD) and the respective literature is inconclusive and limited by inappropriate design with lack of PD control group. The study aims to examine the short-term effect of dopaminergic medication on speech in PD using patients with good motor responsiveness to levodopa challenge compared to a control group of PD patients with poor motor responsiveness. A total of 60 early-stage PD patients were investigated before (OFF) and after (ON) acute levodopa challenge and compared to 30 age-matched healthy controls. PD patients were categorised into two clinical subgroups (PD responders vs. PD nonresponders) according to the comparison of their motor performance based on movement disorder societ"],"journal":["NPJ Parkinson's disease"],"pubmed_title":["Short-term effect of dopaminergic medication on speech in early-stage Parkinson's disease."],"pmcid":["PMC8901688"],"funding_grant_id":["NV19-04-00120"],"pubmed_authors":["Rusz J","Ruzicka E","Tykalova T","Novotny M","Dusek P"],"additional_accession":[]},"is_claimable":false,"name":"Short-term effect of dopaminergic medication on speech in early-stage Parkinson's disease.","description":"The effect of dopaminergic medication on speech has rarely been examined in early-stage Parkinson's disease (PD) and the respective literature is inconclusive and limited by inappropriate design with lack of PD control group. The study aims to examine the short-term effect of dopaminergic medication on speech in PD using patients with good motor responsiveness to levodopa challenge compared to a control group of PD patients with poor motor responsiveness. A total of 60 early-stage PD patients were investigated before (OFF) and after (ON) acute levodopa challenge and compared to 30 age-matched healthy controls. PD patients were categorised into two clinical subgroups (PD responders vs. PD nonresponders) according to the comparison of their motor performance based on movement disorder societ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-22T22:06:25.213Z","creation":"2025-04-06T03:55:33.214Z"},"accession":"S-EPMC8901688","cross_references":{"pubmed":["35256614"],"doi":["10.1038/s41531-022-00286-y"]}}