biostudies-literatureTykalova TMinisterstvo Zdravotnictví Ceské RepublikyMinisterstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic)22https://www.ebi.ac.uk/biostudies/studies/S-EPMC8901688biostudies-literatureUnknown8(1)The effect of dopaminergic medication on speech has rarely been examined in early-stage Parkinson's disease (PD) and the respective literature is inconclusive and limited by inappropriate design with lack of PD control group. The study aims to examine the short-term effect of dopaminergic medication on speech in PD using patients with good motor responsiveness to levodopa challenge compared to a control group of PD patients with poor motor responsiveness. A total of 60 early-stage PD patients were investigated before (OFF) and after (ON) acute levodopa challenge and compared to 30 age-matched healthy controls. PD patients were categorised into two clinical subgroups (PD responders vs. PD nonresponders) according to the comparison of their motor performance based on movement disorder societNPJ Parkinson's diseaseShort-term effect of dopaminergic medication on speech in early-stage Parkinson's disease.PMC8901688NV19-04-00120Rusz JRuzicka ETykalova TNovotny MDusek PfalseShort-term effect of dopaminergic medication on speech in early-stage Parkinson's disease.The effect of dopaminergic medication on speech has rarely been examined in early-stage Parkinson's disease (PD) and the respective literature is inconclusive and limited by inappropriate design with lack of PD control group. The study aims to examine the short-term effect of dopaminergic medication on speech in PD using patients with good motor responsiveness to levodopa challenge compared to a control group of PD patients with poor motor responsiveness. A total of 60 early-stage PD patients were investigated before (OFF) and after (ON) acute levodopa challenge and compared to 30 age-matched healthy controls. PD patients were categorised into two clinical subgroups (PD responders vs. PD nonresponders) according to the comparison of their motor performance based on movement disorder societ2022-01-01T00:00:00Z2022 Mar2025-04-22T22:06:25.213Z2025-04-06T03:55:33.214ZS-EPMC89016883525661410.1038/s41531-022-00286-y