{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Molinaro AM"],"funding":["Helen Glaser, Elvera Olsen, Raymond E. Cooper, and William Martinusen","CDMRP/DoD","NCI NIH HHS","National Institutes of Health","2018 AACR-Johnson &amp; Johnson Lung Cancer Innovation Science","NIH","Robert Magnin Newman Endowed Chair in Neuro-oncology","loglio Collective, and the National Brain Tumor Foundation and by donations from families and friends of John Berardi","NIGMS NIH HHS","NIGMS"],"pagination":["446-457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8902347"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(3)"],"pubmed_abstract":["<h4>Background</h4>Tumor-based classification of human glioma portends patient prognosis, but considerable unexplained survival variability remains. Host factors (eg, age) also strongly influence survival times, partly reflecting a compromised immune system. How blood epigenetic measures of immune characteristics and age augment molecular classifications in glioma survival has not been investigated. We assess the prognostic impact of immune cell fractions and epigenetic age in archived blood across glioma molecular subtypes for the first time.<h4>Methods</h4>We evaluated immune cell fractions and epigenetic age in archived blood from the University of California San Francisco Adult Glioma Study, which included a training set of 197 patients with IDH-wild type, 1p19q intact, TERT wild type "],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["Interactions of Age and Blood Immune Factors and Noninvasive Prediction of Glioma Survival."],"pmcid":["PMC8902347"],"funding_grant_id":["P50 CA097257","R01CA139020","18-90-52-MICH","P20GM1044168299","P50CA097257","R01 CA052689","R01 CA207360","R01CA126831","P20 GM130423","W81XWH-20–1-0778","R01CA52689","P20GM103428","R01 GM103428","R01 CA126831","R01 CA139020","P20 GM103408","P30 CA168524","P20 GM104416","R25 CA112355","R01CA207360","R25CA112355"],"pubmed_authors":["Lee S","Hansen HM","Chunduru P","Anguiano J","Koestler DC","Warrier G","Lee JY","Rice T","McCoy L","Salas LA","Clarke JL","Wiencke JK","Molinaro AM","Wrensch M","Christensen BC","Kelsey KT","Taylor JW","Bracci PM"],"additional_accession":[]},"is_claimable":false,"name":"Interactions of Age and Blood Immune Factors and Noninvasive Prediction of Glioma Survival.","description":"<h4>Background</h4>Tumor-based classification of human glioma portends patient prognosis, but considerable unexplained survival variability remains. Host factors (eg, age) also strongly influence survival times, partly reflecting a compromised immune system. How blood epigenetic measures of immune characteristics and age augment molecular classifications in glioma survival has not been investigated. We assess the prognostic impact of immune cell fractions and epigenetic age in archived blood across glioma molecular subtypes for the first time.<h4>Methods</h4>We evaluated immune cell fractions and epigenetic age in archived blood from the University of California San Francisco Adult Glioma Study, which included a training set of 197 patients with IDH-wild type, 1p19q intact, TERT wild type ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-01T02:24:31.247Z","creation":"2026-04-08T09:15:17.142Z"},"accession":"S-EPMC8902347","cross_references":{"pubmed":["34597382"],"doi":["10.1093/jnci/djab195"]}}