{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou X"],"funding":["Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine"],"pagination":["468-477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8902402"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["<h4>Aims/introduction</h4>The union of dipeptidyl peptidase-4 inhibitors and insulin in patients with type 2 diabetes and chronic kidney disease provides satisfactory glucose management without increasing adverse events (AEs). This research appraised the therapeutic effect and safety of combination therapy in patients with type 2 diabetes and chronic kidney disease.<h4>Materials and methods</h4>We carried out a meta-analysis of randomized controlled trials to analyze AEs, hypoglycemia, serious AEs, severe hypoglycemia, estimated glomerular filtration rate, fasting plasma glucose, glycated hemoglobin, insulin dose, low-density lipoprotein cholesterol, uric acid and weight between combination treatment groups and control groups by searching the Cochrane Library, Excerpta Medica Database (Emb"],"journal":["Journal of diabetes investigation"],"pubmed_title":["Dipeptidyl peptidase-4 inhibitor and insulin combination treatment in type 2 diabetes and chronic kidney disease: A meta-analysis."],"pmcid":["PMC8902402"],"funding_grant_id":["20203005"],"pubmed_authors":["Sun S","Wang H","Zhou X","Shi H","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Dipeptidyl peptidase-4 inhibitor and insulin combination treatment in type 2 diabetes and chronic kidney disease: A meta-analysis.","description":"<h4>Aims/introduction</h4>The union of dipeptidyl peptidase-4 inhibitors and insulin in patients with type 2 diabetes and chronic kidney disease provides satisfactory glucose management without increasing adverse events (AEs). This research appraised the therapeutic effect and safety of combination therapy in patients with type 2 diabetes and chronic kidney disease.<h4>Materials and methods</h4>We carried out a meta-analysis of randomized controlled trials to analyze AEs, hypoglycemia, serious AEs, severe hypoglycemia, estimated glomerular filtration rate, fasting plasma glucose, glycated hemoglobin, insulin dose, low-density lipoprotein cholesterol, uric acid and weight between combination treatment groups and control groups by searching the Cochrane Library, Excerpta Medica Database (Emb","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T08:53:48.381Z","creation":"2025-04-04T08:53:48.381Z"},"accession":"S-EPMC8902402","cross_references":{"pubmed":["34551206"],"doi":["10.1111/jdi.13675"]}}