biostudies-literatureZhou XResearch Project of Guangdong Provincial Bureau of Traditional Chinese Medicine468-477https://www.ebi.ac.uk/biostudies/studies/S-EPMC8902402biostudies-literatureUnknown13(3)<h4>Aims/introduction</h4>The union of dipeptidyl peptidase-4 inhibitors and insulin in patients with type 2 diabetes and chronic kidney disease provides satisfactory glucose management without increasing adverse events (AEs). This research appraised the therapeutic effect and safety of combination therapy in patients with type 2 diabetes and chronic kidney disease.<h4>Materials and methods</h4>We carried out a meta-analysis of randomized controlled trials to analyze AEs, hypoglycemia, serious AEs, severe hypoglycemia, estimated glomerular filtration rate, fasting plasma glucose, glycated hemoglobin, insulin dose, low-density lipoprotein cholesterol, uric acid and weight between combination treatment groups and control groups by searching the Cochrane Library, Excerpta Medica Database (EmbJournal of diabetes investigationDipeptidyl peptidase-4 inhibitor and insulin combination treatment in type 2 diabetes and chronic kidney disease: A meta-analysis.PMC890240220203005Sun SWang HZhou XShi HZhu SfalseDipeptidyl peptidase-4 inhibitor and insulin combination treatment in type 2 diabetes and chronic kidney disease: A meta-analysis.<h4>Aims/introduction</h4>The union of dipeptidyl peptidase-4 inhibitors and insulin in patients with type 2 diabetes and chronic kidney disease provides satisfactory glucose management without increasing adverse events (AEs). This research appraised the therapeutic effect and safety of combination therapy in patients with type 2 diabetes and chronic kidney disease.<h4>Materials and methods</h4>We carried out a meta-analysis of randomized controlled trials to analyze AEs, hypoglycemia, serious AEs, severe hypoglycemia, estimated glomerular filtration rate, fasting plasma glucose, glycated hemoglobin, insulin dose, low-density lipoprotein cholesterol, uric acid and weight between combination treatment groups and control groups by searching the Cochrane Library, Excerpta Medica Database (Emb2022-01-01T00:00:00Z2022 Mar2025-04-04T08:53:48.381Z2025-04-04T08:53:48.381ZS-EPMC89024023455120610.1111/jdi.13675