{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shao Y"],"funding":["Natural Science Foundation of Zhejiang Province","Ningbo University","National Natural Science Foundation of China","Ministry of Education of the People's Republic of China"],"pagination":["101667"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8902612"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["298(3)"],"pubmed_abstract":["In marine environments, organisms are confronted with numerous microbial challenges, although the differential regulation of xenophagy in response to different pathogenic bacterial species remains relatively unknown. Here, we addressed this issue using Apostichopus japonicus as a model. We identified 39 conserved autophagy-related genes by genome-wide screening, which provided a molecular basis for autophagy regulation in sea cucumbers. Furthermore, xenophagy of two Gram-negative bacteria, Vibrio splendidus and Escherichia coli, but not a Gram-positive bacteria, Micrococcus luteus, was observed in different autophagy assays. Surprisingly, a significantly higher autophagy capacity was found in the E. coli-challenged group than in the V. splendidus-challenged group. To confirm these findings"],"journal":["The Journal of biological chemistry"],"pubmed_title":["Xenophagy of invasive bacteria is differentially activated and modulated via a TLR-TRAF6-Beclin1 axis in echinoderms."],"pmcid":["PMC8902612"],"funding_grant_id":["LZ19C190001","32073003"],"pubmed_authors":["Lv Z","Zhang W","Chen K","Li C","Shao Y","Li D","Zhang C","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Xenophagy of invasive bacteria is differentially activated and modulated via a TLR-TRAF6-Beclin1 axis in echinoderms.","description":"In marine environments, organisms are confronted with numerous microbial challenges, although the differential regulation of xenophagy in response to different pathogenic bacterial species remains relatively unknown. Here, we addressed this issue using Apostichopus japonicus as a model. We identified 39 conserved autophagy-related genes by genome-wide screening, which provided a molecular basis for autophagy regulation in sea cucumbers. Furthermore, xenophagy of two Gram-negative bacteria, Vibrio splendidus and Escherichia coli, but not a Gram-positive bacteria, Micrococcus luteus, was observed in different autophagy assays. Surprisingly, a significantly higher autophagy capacity was found in the E. coli-challenged group than in the V. splendidus-challenged group. To confirm these findings","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-31T11:50:38.712Z","creation":"2024-11-10T07:29:00.993Z"},"accession":"S-EPMC8902612","cross_references":{"pubmed":["35120925"],"doi":["10.1016/j.jbc.2022.101667"]}}