{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feehan DD"],"funding":["Queen Elizabeth II Graduate Scholarship","Cystic Fibrosis Canada","Eyes High Doctoral Scholarship, University of Calgary","Canadian Institutes of Health Research","Jessie Bowden Lloyd Professorship in Immunology","CIHR"],"pagination":["e1010325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8903247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Pseudomonas aeruginosa is an opportunistic pathogen that often infects individuals with the genetic disease cystic fibrosis, and contributes to airway blockage and loss of lung function. Natural killer (NK) cells are cytotoxic, granular lymphocytes that are part of the innate immune system. NK cell secretory granules contain the cytolytic proteins granulysin, perforin and granzymes. In addition to their cytotoxic effects on cancer and virally infected cells, NK cells have been shown to play a role in an innate defense against microbes, including bacteria. However, it is not known if NK cells kill extracellular P. aeruginosa or how bacterial killing might occur at the molecular level. Here we show that NK cells directly kill extracellular P. aeruginosa using NK effector molecules. Live cell"],"journal":["PLoS pathogens"],"pubmed_title":["Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H."],"pmcid":["PMC8903247"],"funding_grant_id":["247301","2617"],"pubmed_authors":["Jamil K","Harrison JJ","Feehan DD","Xiang RF","Ogbomo H","Hasell M","Trapani JA","Li SS","Mody CH","Parkins M","Polyak MJ"],"additional_accession":[]},"is_claimable":false,"name":"Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H.","description":"Pseudomonas aeruginosa is an opportunistic pathogen that often infects individuals with the genetic disease cystic fibrosis, and contributes to airway blockage and loss of lung function. Natural killer (NK) cells are cytotoxic, granular lymphocytes that are part of the innate immune system. NK cell secretory granules contain the cytolytic proteins granulysin, perforin and granzymes. In addition to their cytotoxic effects on cancer and virally infected cells, NK cells have been shown to play a role in an innate defense against microbes, including bacteria. However, it is not known if NK cells kill extracellular P. aeruginosa or how bacterial killing might occur at the molecular level. Here we show that NK cells directly kill extracellular P. aeruginosa using NK effector molecules. Live cell","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-26T04:42:32.45Z","creation":"2025-04-06T11:12:42.367Z"},"accession":"S-EPMC8903247","cross_references":{"pubmed":["35202434"],"doi":["10.1371/journal.ppat.1010325"]}}