{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang F"],"funding":["ANPCyT","Secretar?a de Ciencia y T?cnica, Universidad Nacional de R?o Cuarto","Hawaii Community Foundation","NIH","NIGMS NIH HHS"],"pagination":["4408-4412"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(11)"],"pubmed_abstract":["Waikikiamides A-C (<b>1</b>-<b>3</b>), structurally complex diketopiperazine derivatives, and putative biogenic precursors, (+)-semivioxanthin (<b>4</b>), notoamide F (<b>5</b>), and (-)-notoamide A (<b>6</b>), were isolated from <i>Aspergillus</i> sp. FM242. <b>1</b> and <b>2</b>, bearing a hendecacyclic ring system, represent a novel skeleton. <b>3</b> features the first unique heterodimer of two notoamide analogs with an N-O-C bridge. Compounds <b>1</b> and <b>3</b> exhibit antiproliferative activity with IC<sub>50</sub> values in the range of 0.56 to 1.86 μM. The gene clusters mined from the sequenced genome support their putative biosynthetic pathways."],"journal":["Organic letters"],"pubmed_title":["Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain <i>Aspergillus</i> sp. FM242."],"pmcid":["PMC8904076"],"funding_grant_id":["15ADVC-74420","R35 GM128742","P20 GM103466","17CON- 86295","PICT-2016-0116","5P20GM103466","BIO 500","1R35GM128742"],"pubmed_authors":["Zheng SL","Sarotti AM","Ding Y","Li C","Jiang G","Huguet-Tapia JC","Wang F","Cao S","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain <i>Aspergillus</i> sp. FM242.","description":"Waikikiamides A-C (<b>1</b>-<b>3</b>), structurally complex diketopiperazine derivatives, and putative biogenic precursors, (+)-semivioxanthin (<b>4</b>), notoamide F (<b>5</b>), and (-)-notoamide A (<b>6</b>), were isolated from <i>Aspergillus</i> sp. FM242. <b>1</b> and <b>2</b>, bearing a hendecacyclic ring system, represent a novel skeleton. <b>3</b> features the first unique heterodimer of two notoamide analogs with an N-O-C bridge. Compounds <b>1</b> and <b>3</b> exhibit antiproliferative activity with IC<sub>50</sub> values in the range of 0.56 to 1.86 μM. The gene clusters mined from the sequenced genome support their putative biosynthetic pathways.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-06-01T02:34:50.554Z","creation":"2024-10-16T15:02:21.022Z"},"accession":"S-EPMC8904076","cross_references":{"pubmed":["32433885"],"doi":["10.1021/acs.orglett.0c01411"]}}