biostudies-literatureWang FANPCyTSecretar?a de Ciencia y T?cnica, Universidad Nacional de R?o CuartoHawaii Community FoundationNIHNIGMS NIH HHS4408-4412https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904076biostudies-literatureUnknown22(11)Waikikiamides A-C (<b>1</b>-<b>3</b>), structurally complex diketopiperazine derivatives, and putative biogenic precursors, (+)-semivioxanthin (<b>4</b>), notoamide F (<b>5</b>), and (-)-notoamide A (<b>6</b>), were isolated from <i>Aspergillus</i> sp. FM242. <b>1</b> and <b>2</b>, bearing a hendecacyclic ring system, represent a novel skeleton. <b>3</b> features the first unique heterodimer of two notoamide analogs with an N-O-C bridge. Compounds <b>1</b> and <b>3</b> exhibit antiproliferative activity with IC₅₀ values in the range of 0.56 to 1.86 μM. The gene clusters mined from the sequenced genome support their putative biosynthetic pathways.Organic lettersWaikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain <i>Aspergillus</i> sp. FM242.PMC890407615ADVC-74420R35 GM128742P20 GM10346617CON- 86295PICT-2016-01165P20GM103466BIO 5001R35GM128742Zheng SLSarotti AMDing YLi CJiang GHuguet-Tapia JCWang FCao SWu XfalseWaikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain <i>Aspergillus</i> sp. FM242.Waikikiamides A-C (<b>1</b>-<b>3</b>), structurally complex diketopiperazine derivatives, and putative biogenic precursors, (+)-semivioxanthin (<b>4</b>), notoamide F (<b>5</b>), and (-)-notoamide A (<b>6</b>), were isolated from <i>Aspergillus</i> sp. FM242. <b>1</b> and <b>2</b>, bearing a hendecacyclic ring system, represent a novel skeleton. <b>3</b> features the first unique heterodimer of two notoamide analogs with an N-O-C bridge. Compounds <b>1</b> and <b>3</b> exhibit antiproliferative activity with IC₅₀ values in the range of 0.56 to 1.86 μM. The gene clusters mined from the sequenced genome support their putative biosynthetic pathways.2020-01-01T00:00:00Z2020 Jun2026-06-01T02:34:50.554Z2024-10-16T15:02:21.022ZS-EPMC89040763243388510.1021/acs.orglett.0c01411