biostudies-literatureUnknown77Tang S<h4>Background</h4>Although dysfunction of large-scale brain networks has been frequently demonstrated in patients with α-Synucleinopathy (α-Syn, i.e., Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy), a consistent pattern of dysfunction remains unclear. We aim to investigate network dysfunction in patients with α-Syn through a meta-analysis.<h4>Methods</h4>Whole-brain seed-based resting-state functional connectivity studies (published before September 1st, 2020 in English) comparing α-Syn patients with healthy controls (HC) were retrieved from electronic databases (PubMed, Web of Science, and EMBASE). Seeds from each study were categorized into networks by their location within a priori functional networks. Seed-based effect size mapping with Permutation of SubEBioMedicine103915https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904227biostudies-literatureLarge-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity.PMC8904227Liu YAbrigo JMMok VCTang SChan JWWang YChau SWChu WCWing YKfalseLarge-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity.<h4>Background</h4>Although dysfunction of large-scale brain networks has been frequently demonstrated in patients with α-Synucleinopathy (α-Syn, i.e., Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy), a consistent pattern of dysfunction remains unclear. We aim to investigate network dysfunction in patients with α-Syn through a meta-analysis.<h4>Methods</h4>Whole-brain seed-based resting-state functional connectivity studies (published before September 1st, 2020 in English) comparing α-Syn patients with healthy controls (HC) were retrieved from electronic databases (PubMed, Web of Science, and EMBASE). Seeds from each study were categorized into networks by their location within a priori functional networks. Seed-based effect size mapping with Permutation of Sub2022-01-01T00:00:00Z2022 Mar2025-04-04T08:53:49.553Z2025-04-04T08:53:49.553ZS-EPMC89042273525957410.1016/j.ebiom.2022.103915