{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["91(3)"],"submitter":["Barta H"],"pubmed_abstract":["<h4>Background</h4>Prognostic value of proton MR spectroscopy (H-MRS) in hypoxic-ischemic encephalopathy (HIE) is acknowledged; however, effects of gestational age (GA) and postnatal age (PA) on prediction and metabolite levels are unknown.<h4>Methods</h4>One hundred and sixty-nine newborns with moderate-to-severe HIE were studied, having ≥1 H-MRS scan during postnatal days 0-14 and known neurodevelopmental outcome (Bayley-II score/cerebral palsy/death). Initial scans were categorized by PA (day 1-3/4-6/≥7), and metabolite ratios were compared by predictive value. Metabolite dynamics were assessed in a total of 214 scans performed in the study population, using regression modeling, with predictors GA, PA, and outcome.<h4>Results</h4>N-acetyl-aspartate (NAA)/creatine (Cr) and myo-inositol ("],"journal":["Pediatric research"],"pagination":["581-589"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904256"],"repository":["biostudies-literature"],"pubmed_title":["Predictive performance and metabolite dynamics of proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy."],"pmcid":["PMC8904256"],"pubmed_authors":["Barta H","Kovacs L","Schiever N","Jermendy A","Szabo M","Rudas G"],"additional_accession":[]},"is_claimable":false,"name":"Predictive performance and metabolite dynamics of proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy.","description":"<h4>Background</h4>Prognostic value of proton MR spectroscopy (H-MRS) in hypoxic-ischemic encephalopathy (HIE) is acknowledged; however, effects of gestational age (GA) and postnatal age (PA) on prediction and metabolite levels are unknown.<h4>Methods</h4>One hundred and sixty-nine newborns with moderate-to-severe HIE were studied, having ≥1 H-MRS scan during postnatal days 0-14 and known neurodevelopmental outcome (Bayley-II score/cerebral palsy/death). Initial scans were categorized by PA (day 1-3/4-6/≥7), and metabolite ratios were compared by predictive value. Metabolite dynamics were assessed in a total of 214 scans performed in the study population, using regression modeling, with predictors GA, PA, and outcome.<h4>Results</h4>N-acetyl-aspartate (NAA)/creatine (Cr) and myo-inositol (","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-03-27T16:43:25.946Z","creation":"2025-04-04T12:56:34.645Z"},"accession":"S-EPMC8904256","cross_references":{"pubmed":["34489532"],"doi":["10.1038/s41390-021-01626-z"]}}