biostudies-literatureUnknown91(3)Barta H<h4>Background</h4>Prognostic value of proton MR spectroscopy (H-MRS) in hypoxic-ischemic encephalopathy (HIE) is acknowledged; however, effects of gestational age (GA) and postnatal age (PA) on prediction and metabolite levels are unknown.<h4>Methods</h4>One hundred and sixty-nine newborns with moderate-to-severe HIE were studied, having ≥1 H-MRS scan during postnatal days 0-14 and known neurodevelopmental outcome (Bayley-II score/cerebral palsy/death). Initial scans were categorized by PA (day 1-3/4-6/≥7), and metabolite ratios were compared by predictive value. Metabolite dynamics were assessed in a total of 214 scans performed in the study population, using regression modeling, with predictors GA, PA, and outcome.<h4>Results</h4>N-acetyl-aspartate (NAA)/creatine (Cr) and myo-inositol (Pediatric research581-589https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904256biostudies-literaturePredictive performance and metabolite dynamics of proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy.PMC8904256Barta HKovacs LSchiever NJermendy ASzabo MRudas GfalsePredictive performance and metabolite dynamics of proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy.<h4>Background</h4>Prognostic value of proton MR spectroscopy (H-MRS) in hypoxic-ischemic encephalopathy (HIE) is acknowledged; however, effects of gestational age (GA) and postnatal age (PA) on prediction and metabolite levels are unknown.<h4>Methods</h4>One hundred and sixty-nine newborns with moderate-to-severe HIE were studied, having ≥1 H-MRS scan during postnatal days 0-14 and known neurodevelopmental outcome (Bayley-II score/cerebral palsy/death). Initial scans were categorized by PA (day 1-3/4-6/≥7), and metabolite ratios were compared by predictive value. Metabolite dynamics were assessed in a total of 214 scans performed in the study population, using regression modeling, with predictors GA, PA, and outcome.<h4>Results</h4>N-acetyl-aspartate (NAA)/creatine (Cr) and myo-inositol (2022-01-01T00:00:00Z2022 Feb2026-03-27T16:43:25.946Z2025-04-04T12:56:34.645ZS-EPMC89042563448953210.1038/s41390-021-01626-z