{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Murthy SRK"],"pubmed_abstract":["Breast cancer is the leading cause of cancer death among women. Triple-negative breast cancer (TNBC) has a poor prognosis and frequently relapses early compared with other subtypes. The Cold Atmospheric Plasma (CAP) is a promising therapy for prognostically poor breast cancer such as TNBC. The Canady Helios Cold Plasma (CHCP) induces cell death in the TNBC cell line without thermal damage, however, the mechanism of cell death by CAP treatment is ambiguous and the mechanism of resistance to cell death in some subset of cells has not been addressed. We investigate the expression profile of 48 apoptotic and 35 oxidative gene markers after CHCP treatment in six different types of breast cancer cell lines including luminal A (ER<sup>+</sup> PR<sup>+/-</sup>HER2<sup>-</sup>), luminal B (ER<sup>+"],"journal":["Scientific reports"],"pagination":["4038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904455"],"repository":["biostudies-literature"],"pubmed_title":["BCL2A1 regulates Canady Helios Cold Plasma-induced cell death in triple-negative breast cancer."],"pmcid":["PMC8904455"],"pubmed_authors":["Murthy SRK","Jones O","Zhuang T","Basadonna G","Canady J","Keidar M","Cheng X","Ly L"],"additional_accession":[]},"is_claimable":false,"name":"BCL2A1 regulates Canady Helios Cold Plasma-induced cell death in triple-negative breast cancer.","description":"Breast cancer is the leading cause of cancer death among women. Triple-negative breast cancer (TNBC) has a poor prognosis and frequently relapses early compared with other subtypes. The Cold Atmospheric Plasma (CAP) is a promising therapy for prognostically poor breast cancer such as TNBC. The Canady Helios Cold Plasma (CHCP) induces cell death in the TNBC cell line without thermal damage, however, the mechanism of cell death by CAP treatment is ambiguous and the mechanism of resistance to cell death in some subset of cells has not been addressed. We investigate the expression profile of 48 apoptotic and 35 oxidative gene markers after CHCP treatment in six different types of breast cancer cell lines including luminal A (ER<sup>+</sup> PR<sup>+/-</sup>HER2<sup>-</sup>), luminal B (ER<sup>+","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-05T11:07:39.379Z","creation":"2025-04-05T11:07:39.379Z"},"accession":"S-EPMC8904455","cross_references":{"pubmed":["35260587"],"doi":["10.1038/s41598-022-07027-4"]}}