{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kiyokoba R"],"funding":["MEXT|Japan Society for the Promotion of Science","Japan Association of Obstetricians and Gynecologists Ogyaa Donation Foundation"],"pagination":["4056"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction. However, little is known about how these factors affect placental function. We investigated how mitochondrial dysfunction and high hCG expression affected placental function in unexplained FGR and PE/FGR. We observed elevated expression of hCGβ and growth differentiation factor 15 mRNA and protein levels in the placenta with both diseases. Likewise, antiangiogenic factors, such as Ang2, IP10, sFlt1, IL8, IL1B, and TNFα, were also upregulated at the mRNA level. In addition, the expression of COXI and COXII which encoded by mitochondrial DNA were significantly decreased in bot"],"journal":["Scientific reports"],"pubmed_title":["Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction."],"pmcid":["PMC8904547"],"funding_grant_id":["20H00530","17H01550","18K15421"],"pubmed_authors":["Kiyokoba R","Yagi M","Uchiumi T","Kato K","Kang D","Toshima T","Tsukahara S","Fujita Y"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction.","description":"Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction. However, little is known about how these factors affect placental function. We investigated how mitochondrial dysfunction and high hCG expression affected placental function in unexplained FGR and PE/FGR. We observed elevated expression of hCGβ and growth differentiation factor 15 mRNA and protein levels in the placenta with both diseases. Likewise, antiangiogenic factors, such as Ang2, IP10, sFlt1, IL8, IL1B, and TNFα, were also upregulated at the mRNA level. In addition, the expression of COXI and COXII which encoded by mitochondrial DNA were significantly decreased in bot","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T20:50:28.166Z","creation":"2025-04-04T20:50:28.166Z"},"accession":"S-EPMC8904547","cross_references":{"pubmed":["35260712"],"doi":["10.1038/s41598-022-07893-y"]}}