biostudies-literatureUnknown10(3)Li L<h4>Background</h4>Recurrent implantation failure (RIF) is a critical problem for assisted reproduction technology. High-quality embryos and the synchronization endometrium both have great significance. How to get the optimal endometrial receptivity is a challenge for implantation and pregnancy of infertile patients with RIF. The objective of this study is to investigate personalized protocol of frozen-thawed embryo transfer (FET) cycles, and its effect on clinical outcomes in patients with RIF.<h4>Methods</h4>We chose 91 RIF patients from January 2017 to June 2019 in the Reproductive Medicine Center of the First Hospital of Lanzhou University. A total of 100 FET cycles were undertaken with a gonadotropin-releasing hormone agonist (GnRH-agonist) protocol combined with hormone replacement tAnnals of translational medicine131https://www.ebi.ac.uk/biostudies/studies/S-EPMC8904980biostudies-literatureClinical outcomes of personalized frozen-thawed embryo transfer timing for patients with recurrent implantation failure.PMC8904980Liu LZhang XFu YLiang LLi LKou ZfalseClinical outcomes of personalized frozen-thawed embryo transfer timing for patients with recurrent implantation failure.<h4>Background</h4>Recurrent implantation failure (RIF) is a critical problem for assisted reproduction technology. High-quality embryos and the synchronization endometrium both have great significance. How to get the optimal endometrial receptivity is a challenge for implantation and pregnancy of infertile patients with RIF. The objective of this study is to investigate personalized protocol of frozen-thawed embryo transfer (FET) cycles, and its effect on clinical outcomes in patients with RIF.<h4>Methods</h4>We chose 91 RIF patients from January 2017 to June 2019 in the Reproductive Medicine Center of the First Hospital of Lanzhou University. A total of 100 FET cycles were undertaken with a gonadotropin-releasing hormone agonist (GnRH-agonist) protocol combined with hormone replacement t2022-01-01T00:00:00Z2022 Feb2025-04-27T03:21:27.535Z2025-04-06T18:47:55.181ZS-EPMC89049803528455410.21037/atm-22-161