{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Li X"],"pubmed_abstract":["Skeletal muscle, the main source of animal meat products, contains muscle fiber as a key unit. It is well known that transformation takes place between different types of muscle fibers, however, the conversion mechanism is not clear. In a previous study, our lab has demonstrated that there is a decrease in type I muscle fibers and an increase in type IIB muscle fibers in skeletal muscle of myostatin gene-edited Meishan pigs. Very interestingly, we observed the down regulation of miR-208b expression and an increase in expression the predicted target gene Mettl8 (Methyltransferase like 8) in skeletal muscle of MSTN gene-edited Meishan pigs. These results reveal that there is a potential connection between the conversion of skeletal muscle fiber types and miR-208b and Mettl8 expression. In th"],"journal":["Frontiers in genetics"],"pagination":["820464"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8905228"],"repository":["biostudies-literature"],"pubmed_title":["MiR-208b Regulates the Conversion of Skeletal Muscle Fiber Types by Inhibiting Mettl8 Expression."],"pmcid":["PMC8905228"],"pubmed_authors":["Bi H","Li X","Cui W","Xie S"],"additional_accession":[]},"is_claimable":false,"name":"MiR-208b Regulates the Conversion of Skeletal Muscle Fiber Types by Inhibiting Mettl8 Expression.","description":"Skeletal muscle, the main source of animal meat products, contains muscle fiber as a key unit. It is well known that transformation takes place between different types of muscle fibers, however, the conversion mechanism is not clear. In a previous study, our lab has demonstrated that there is a decrease in type I muscle fibers and an increase in type IIB muscle fibers in skeletal muscle of myostatin gene-edited Meishan pigs. Very interestingly, we observed the down regulation of miR-208b expression and an increase in expression the predicted target gene Mettl8 (Methyltransferase like 8) in skeletal muscle of MSTN gene-edited Meishan pigs. These results reveal that there is a potential connection between the conversion of skeletal muscle fiber types and miR-208b and Mettl8 expression. In th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T08:53:42.578Z","creation":"2025-04-04T08:53:42.578Z"},"accession":"S-EPMC8905228","cross_references":{"pubmed":["35281804"],"doi":["10.3389/fgene.2022.820464"]}}