{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hamm SR"],"funding":["Carlsbergfondet","Novo Nordisk Fonden"],"pagination":["832501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8905653"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<h4>Background</h4>Previous studies have indicated inferior responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients. We examined the development of anti-receptor-binding domain (RBD) immunoglobulin G (IgG) after two doses of BNT162b2b in SOT recipients 6 months after vaccination and compared to that of immunocompetent controls.<h4>Methods</h4>We measured anti-RBD IgG after two doses of BNT162b2 in 200 SOT recipients and 200 matched healthy controls up to 6 months after first vaccination. Anti-RBD IgG concentration and neutralizing capacity of antibodies were measured at first and second doses of BNT162b2 and 2 and 6 months after the first dose. T-cell responses were measured 6 months after the first dose.<h4>Results</"],"journal":["Frontiers in immunology"],"pubmed_title":["Decline in Antibody Concentration 6 Months After Two Doses of SARS-CoV-2 BNT162b2 Vaccine in Solid Organ Transplant Recipients and Healthy Controls."],"pmcid":["PMC8905653"],"funding_grant_id":["NNF20SA0063505"],"pubmed_authors":["Bundgaard H","Hilsted LM","Hansen CB","Garred P","Madsen JR","Fogh K","Heftdal LD","Poulsen JR","Frikke-Schmidt R","Perch M","Ostrowski SR","Sorensen E","Almagro Armenteros JJ","Harboe ZB","Pries-Heje MM","Hasselbalch RB","Sorensen SS","Knudsen AD","Rasmussen A","Perez-Alos L","Iversen K","Hamm SR","Moller DL","Nielsen SD"],"additional_accession":[]},"is_claimable":false,"name":"Decline in Antibody Concentration 6 Months After Two Doses of SARS-CoV-2 BNT162b2 Vaccine in Solid Organ Transplant Recipients and Healthy Controls.","description":"<h4>Background</h4>Previous studies have indicated inferior responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients. We examined the development of anti-receptor-binding domain (RBD) immunoglobulin G (IgG) after two doses of BNT162b2b in SOT recipients 6 months after vaccination and compared to that of immunocompetent controls.<h4>Methods</h4>We measured anti-RBD IgG after two doses of BNT162b2 in 200 SOT recipients and 200 matched healthy controls up to 6 months after first vaccination. Anti-RBD IgG concentration and neutralizing capacity of antibodies were measured at first and second doses of BNT162b2 and 2 and 6 months after the first dose. T-cell responses were measured 6 months after the first dose.<h4>Results</","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T20:23:21.885Z","creation":"2025-04-04T20:23:21.885Z"},"accession":"S-EPMC8905653","cross_references":{"pubmed":["35281023"],"doi":["10.3389/fimmu.2022.832501"]}}