{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Pan P"],"pubmed_abstract":["<i>Acinetobacter baumannii</i> is a type of bacterial nosocomial infection with severe drug resistance. Hemolysin co-regulated protein (Hcp) is a marker of activated type VI secretion system (T6SS), a key secretory system that promotes Gram-negative bacteria colonization, adhesion, and invasion of host cells. Hcp is also regulated by iron ions (Fe). In this study, an ATCC17978 <i>hcp</i> deletion strain (ATCC17978Δ<i>hcp</i>), an <i>hcp</i> complement strain (ATCC17978Δ<i>hcp<sup>+</sup></i> ), and an <i>A. baumannii</i>-green fluorescent protein (GFP) strain were constructed and used to investigate the role of <i>hcp</i> in bacterial adhesion to cells (human pulmonary alveolar epithelial cells (HPAEpiC)) and biofilm formation. Our results indicate that the inhibitory concentrations of the"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["761604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8905654"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Hcp Iron Ion Regulation on the Interaction Between <i>Acinetobacter baumannii</i> With Human Pulmonary Alveolar Epithelial Cells and Biofilm Formation."],"pmcid":["PMC8905654"],"pubmed_authors":["Cheng T","Chen Q","Yang Y","Wei C","Pan P","Chen Y","Yu D","Wang X","Wan H"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Hcp Iron Ion Regulation on the Interaction Between <i>Acinetobacter baumannii</i> With Human Pulmonary Alveolar Epithelial Cells and Biofilm Formation.","description":"<i>Acinetobacter baumannii</i> is a type of bacterial nosocomial infection with severe drug resistance. Hemolysin co-regulated protein (Hcp) is a marker of activated type VI secretion system (T6SS), a key secretory system that promotes Gram-negative bacteria colonization, adhesion, and invasion of host cells. Hcp is also regulated by iron ions (Fe). In this study, an ATCC17978 <i>hcp</i> deletion strain (ATCC17978Δ<i>hcp</i>), an <i>hcp</i> complement strain (ATCC17978Δ<i>hcp<sup>+</sup></i> ), and an <i>A. baumannii</i>-green fluorescent protein (GFP) strain were constructed and used to investigate the role of <i>hcp</i> in bacterial adhesion to cells (human pulmonary alveolar epithelial cells (HPAEpiC)) and biofilm formation. Our results indicate that the inhibitory concentrations of the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T07:06:06.984Z","creation":"2024-11-12T19:09:41.002Z"},"accession":"S-EPMC8905654","cross_references":{"pubmed":["35281445"],"doi":["10.3389/fcimb.2022.761604"]}}