{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["376"],"submitter":["Harding C"],"pubmed_abstract":["<h4>Objective</h4>To test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections with the current standard prophylaxis of daily low dose antibiotics.<h4>Design</h4>Multicentre, open label, randomised, non-inferiority trial.<h4>Setting</h4>Eight centres in the UK, recruiting from June 2016 to June 2018.<h4>Participants</h4>Women aged ≥18 years with recurrent urinary tract infections, requiring prophylactic treatment.<h4>Interventions</h4>Random assignment (1:1, using permuted blocks of variable length via a web based system) to receive antibiotic prophylaxis or methenamine hippurate for 12 months. Treatment allocation was not masked and crossover between arms was allowed.<h4>Main outcome measure</h4>Absolute difference in incidence of symptoma"],"journal":["BMJ (Clinical research ed.)"],"pagination":["e068229"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8905684"],"repository":["biostudies-literature"],"pubmed_title":["Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial."],"pmcid":["PMC8905684"],"pubmed_authors":["Carnell S","Thiruchelvam N","Abouhajar A","Hussain Z","Eardley I","Harding C","Pickard R","Lecouturier J","Watson G","Currer S","King W","Walton K","Guerrero K","Lazarowicz H","Ali A","Vale L","Forbes R","Chadwick T","Homer T","Mossop H","Pearce I"],"additional_accession":[]},"is_claimable":false,"name":"Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial.","description":"<h4>Objective</h4>To test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections with the current standard prophylaxis of daily low dose antibiotics.<h4>Design</h4>Multicentre, open label, randomised, non-inferiority trial.<h4>Setting</h4>Eight centres in the UK, recruiting from June 2016 to June 2018.<h4>Participants</h4>Women aged ≥18 years with recurrent urinary tract infections, requiring prophylactic treatment.<h4>Interventions</h4>Random assignment (1:1, using permuted blocks of variable length via a web based system) to receive antibiotic prophylaxis or methenamine hippurate for 12 months. Treatment allocation was not masked and crossover between arms was allowed.<h4>Main outcome measure</h4>Absolute difference in incidence of symptoma","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-21T23:10:27.186Z","creation":"2025-04-05T19:06:32.915Z"},"accession":"S-EPMC8905684","cross_references":{"pubmed":["35264408"],"doi":["10.1136/bmj-2021-0068229"]}}