{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Li J"],"pubmed_abstract":["<h4>Background</h4>This study aims to explore the relationship between surgically-induced ankle instability and posttraumatic osteoarthritis (PTOA) in a mouse model, and to provide reference for clinical practice.<h4>Results</h4>Ligamentectomy was performed on 24 eight-week-old male C57BL/6 J mice, which were divided into three groups. Both the anterior talofibular ligament (ATFL) and the calcaneofibular ligament (CFL) were severed in the CFL + ATFL group, while only the CFL was removed in the CFL group. The SHAM group was set as the blank control group. A wheel-running device was used to accelerate the development of ankle osteoarthritis (OA). Balance measurement, footprint analysis, and histological analysis were used to assess the degree of ankle instability and OA. According to the bal"],"journal":["BMC musculoskeletal disorders"],"pagination":["223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8905815"],"repository":["biostudies-literature"],"pubmed_title":["Ligamentous injury-induced ankle instability causing posttraumatic osteoarthritis in a mouse model."],"pmcid":["PMC8905815"],"pubmed_authors":["Yang H","He F","Li J","Gu X","Chen Z","Luo Z","Zhang H","Yu J","Cheng Y","Gao C"],"additional_accession":[]},"is_claimable":false,"name":"Ligamentous injury-induced ankle instability causing posttraumatic osteoarthritis in a mouse model.","description":"<h4>Background</h4>This study aims to explore the relationship between surgically-induced ankle instability and posttraumatic osteoarthritis (PTOA) in a mouse model, and to provide reference for clinical practice.<h4>Results</h4>Ligamentectomy was performed on 24 eight-week-old male C57BL/6 J mice, which were divided into three groups. Both the anterior talofibular ligament (ATFL) and the calcaneofibular ligament (CFL) were severed in the CFL + ATFL group, while only the CFL was removed in the CFL group. The SHAM group was set as the blank control group. A wheel-running device was used to accelerate the development of ankle osteoarthritis (OA). Balance measurement, footprint analysis, and histological analysis were used to assess the degree of ankle instability and OA. According to the bal","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T18:35:57.597Z","creation":"2025-04-06T15:50:35.598Z"},"accession":"S-EPMC8905815","cross_references":{"pubmed":["35260140"],"doi":["10.1186/s12891-022-05164-5"]}}