biostudies-literatureJin JYProvincial Natural Science Foundation of HumanProvincial Science and Technology Department Foundation of Humane24243https://www.ebi.ac.uk/biostudies/studies/S-EPMC8906030biostudies-literatureUnknown36(3)<h4>Background</h4>Hypophosphatemia is mainly characterized by hypophosphatemia and a low level of 1alpha,25-Dihydroxyvitamin D2 (1,25-(OH)₂ D2) and/or 1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)₂ D3) in the blood. Previous studies have demonstrated that variants in PHEX and FGF23 are primarily responsible for this disease. Although patients with variants of these two genes share almost the same symptoms, they exhibit the different hereditary pattern, X-link dominant and autosome dominant, respectively. Three-dimensional (3D) printing is a method which can accurately reconstruct physical objects, and its applications in orthopedics can contribute to realizing a more accurate surgical performance and a better outcome.<h4>Methods</h4>An X-linked hypophosphatemia (XLH) famiJournal of clinical laboratory analysisGenetic analysis combined with 3D-printing assistant surgery in diagnosis and treatment for an X-linked hypophosphatemia patient.PMC89060302021ZK42182019JJ40517Jin JYTang KXiang RZhang LYZeng LLiang JYGuo SfalseGenetic analysis combined with 3D-printing assistant surgery in diagnosis and treatment for an X-linked hypophosphatemia patient.<h4>Background</h4>Hypophosphatemia is mainly characterized by hypophosphatemia and a low level of 1alpha,25-Dihydroxyvitamin D2 (1,25-(OH)₂ D2) and/or 1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)₂ D3) in the blood. Previous studies have demonstrated that variants in PHEX and FGF23 are primarily responsible for this disease. Although patients with variants of these two genes share almost the same symptoms, they exhibit the different hereditary pattern, X-link dominant and autosome dominant, respectively. Three-dimensional (3D) printing is a method which can accurately reconstruct physical objects, and its applications in orthopedics can contribute to realizing a more accurate surgical performance and a better outcome.<h4>Methods</h4>An X-linked hypophosphatemia (XLH) fami2022-01-01T00:00:00Z2022 Mar2026-05-31T20:56:08.507Z2024-11-10T07:31:48.85ZS-EPMC89060303510685710.1002/jcla.24243