{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boothby IC"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIAMS NIH HHS","NIH HHS","NIGMS NIH HHS"],"pagination":["667-672"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8906225"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["599(7886)"],"pubmed_abstract":["Inflammation early in life can prime the local immune milieu of peripheral tissues, which can cause lasting changes in immunological tone that confer disease protection or susceptibility<sup>1</sup>. The cellular and molecular mechanisms that prompt changes in immune tone in many nonlymphoid tissues remain largely unknown. Here we find that time-limited neonatal inflammation induced by a transient reduction in neonatal regulatory T cells causes a dysregulation of subcutaneous tissue in mouse skin. This is accompanied by the selective accumulation of type 2 helper T (T<sub>H</sub>2) cells within a distinct microanatomical niche. T<sub>H</sub>2 cells are maintained into adulthood through interactions with a fibroblast population in skin fascia that we refer to as T<sub>H</sub>2-interacting f"],"journal":["Nature"],"pubmed_title":["Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin."],"pmcid":["PMC8906225"],"funding_grant_id":["T32 GM007618","P30 DK063720","R01 AR077553","R01 AR071944","S10 OD021822","T32 AR079068","T32 AI007334","R21 AI071944","S10 OD021664","F30 AI147364"],"pubmed_authors":["Cohen JN","Habrylo I","Boothby IC","Chan JD","Clancy S","McCalmont TH","Boda DP","Harris HW","Lowe MM","Yates AE","Neuhaus IM","Pauli M","Kwan EY","Molofsky AB","Rosenblum MD","Kinet MJ"],"additional_accession":[]},"is_claimable":false,"name":"Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.","description":"Inflammation early in life can prime the local immune milieu of peripheral tissues, which can cause lasting changes in immunological tone that confer disease protection or susceptibility<sup>1</sup>. The cellular and molecular mechanisms that prompt changes in immune tone in many nonlymphoid tissues remain largely unknown. Here we find that time-limited neonatal inflammation induced by a transient reduction in neonatal regulatory T cells causes a dysregulation of subcutaneous tissue in mouse skin. This is accompanied by the selective accumulation of type 2 helper T (T<sub>H</sub>2) cells within a distinct microanatomical niche. T<sub>H</sub>2 cells are maintained into adulthood through interactions with a fibroblast population in skin fascia that we refer to as T<sub>H</sub>2-interacting f","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-04-08T17:30:15.648Z","creation":"2025-06-01T12:09:33.013Z"},"accession":"S-EPMC8906225","cross_references":{"pubmed":["34707292"],"doi":["10.1038/s41586-021-04044-7"]}}