{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32(1)"],"submitter":["Gorla R"],"pubmed_abstract":["<h4>Objectives</h4>To compare device success and paravalvular leak rates of 3 new-generation transcatheter aortic valve replacement devices in patients with bicuspid aortic valve stenosis and to test their biomechanical performance in a computer-based simulation model of aortic root with increasing ellipticity.<h4>Methods</h4>This retrospective multicentre study included 56 bicuspid aortic valve patients undergoing transcatheter aortic valve replacement with new-generation devices: Lotus/Lotus Edge (N = 15; 27%), Evolut-R (N = 20; 36%) and ACURATE neo (N = 21; 37%). Three virtual simulation models of aortic root with increasing index of eccentricity (0-0.25-0.5) were implemented. Stress distribution, stent-root contact area and paravalvular orifice area were computed.<h4>Results</h4>Device"],"journal":["Interactive cardiovascular and thoracic surgery"],"pagination":["20-28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8906794"],"repository":["biostudies-literature"],"pubmed_title":["Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices."],"pmcid":["PMC8906794"],"pubmed_authors":["Brambilla N","Bianchi G","Casenghi M","Reimers B","Regazzoli D","Popolo Rubbio A","Bedogni F","Gorla R","De Marco F","Auricchio F","Testa L","Castriota F","Finotello A","Acerbi E","Morganti S"],"additional_accession":[]},"is_claimable":false,"name":"Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices.","description":"<h4>Objectives</h4>To compare device success and paravalvular leak rates of 3 new-generation transcatheter aortic valve replacement devices in patients with bicuspid aortic valve stenosis and to test their biomechanical performance in a computer-based simulation model of aortic root with increasing ellipticity.<h4>Methods</h4>This retrospective multicentre study included 56 bicuspid aortic valve patients undergoing transcatheter aortic valve replacement with new-generation devices: Lotus/Lotus Edge (N = 15; 27%), Evolut-R (N = 20; 36%) and ACURATE neo (N = 21; 37%). Three virtual simulation models of aortic root with increasing index of eccentricity (0-0.25-0.5) were implemented. Stress distribution, stent-root contact area and paravalvular orifice area were computed.<h4>Results</h4>Device","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-04T20:50:39.795Z","creation":"2025-04-04T20:50:39.795Z"},"accession":"S-EPMC8906794","cross_references":{"pubmed":["33201993"],"doi":["10.1093/icvts/ivaa231"]}}