biostudies-literatureUnknown32(1)Gorla R<h4>Objectives</h4>To compare device success and paravalvular leak rates of 3 new-generation transcatheter aortic valve replacement devices in patients with bicuspid aortic valve stenosis and to test their biomechanical performance in a computer-based simulation model of aortic root with increasing ellipticity.<h4>Methods</h4>This retrospective multicentre study included 56 bicuspid aortic valve patients undergoing transcatheter aortic valve replacement with new-generation devices: Lotus/Lotus Edge (N = 15; 27%), Evolut-R (N = 20; 36%) and ACURATE neo (N = 21; 37%). Three virtual simulation models of aortic root with increasing index of eccentricity (0-0.25-0.5) were implemented. Stress distribution, stent-root contact area and paravalvular orifice area were computed.<h4>Results</h4>DeviceInteractive cardiovascular and thoracic surgery20-28https://www.ebi.ac.uk/biostudies/studies/S-EPMC8906794biostudies-literatureOutcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices.PMC8906794Brambilla NBianchi GCasenghi MReimers BRegazzoli DPopolo Rubbio ABedogni FGorla RDe Marco FAuricchio FTesta LCastriota FFinotello AAcerbi EMorganti SfalseOutcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices.<h4>Objectives</h4>To compare device success and paravalvular leak rates of 3 new-generation transcatheter aortic valve replacement devices in patients with bicuspid aortic valve stenosis and to test their biomechanical performance in a computer-based simulation model of aortic root with increasing ellipticity.<h4>Methods</h4>This retrospective multicentre study included 56 bicuspid aortic valve patients undergoing transcatheter aortic valve replacement with new-generation devices: Lotus/Lotus Edge (N = 15; 27%), Evolut-R (N = 20; 36%) and ACURATE neo (N = 21; 37%). Three virtual simulation models of aortic root with increasing index of eccentricity (0-0.25-0.5) were implemented. Stress distribution, stent-root contact area and paravalvular orifice area were computed.<h4>Results</h4>Device2021-01-01T00:00:00Z2021 Jan2025-04-04T20:50:39.795Z2025-04-04T20:50:39.795ZS-EPMC89067943320199310.1093/icvts/ivaa231