{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chintala S"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","School of Pharmacy, University of Missouri-Kansas City","University of Missouri"],"pagination":["1506-1514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8906801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(4)"],"pubmed_abstract":["In this work, we have brought the release of glucagon under the control of light. The aim of this approach is to allow minimally invasive, two-hormone control of blood glucose. Glucagon has two major challenges associated with its therapeutic application: (1) the required amount and timing of glucagon release is highly variable, and (2) glucagon rapidly fibrillates in solution, forming aggregates that are inactive. We have developed a light activated glucagon trimer, in which we have joined three glucagon molecules via light cleaved linkers. We demonstrated that this material can be stimulated by light to release glucagon in a predictable manner. In addition, we demonstrated that in the absence of light, the trimer does not form fibrils and thus releases normal unfibrillated glucagon upon "],"journal":["ACS biomaterials science & engineering"],"pubmed_title":["A Light Activated Glucagon Trimer with Resistance to Fibrillation."],"pmcid":["PMC8906801"],"funding_grant_id":["DP3 DK106921","R01DK123689","R01 DK123689","DP3DK106921"],"pubmed_authors":["Chintala S","Friedman SH"],"additional_accession":[]},"is_claimable":false,"name":"A Light Activated Glucagon Trimer with Resistance to Fibrillation.","description":"In this work, we have brought the release of glucagon under the control of light. The aim of this approach is to allow minimally invasive, two-hormone control of blood glucose. Glucagon has two major challenges associated with its therapeutic application: (1) the required amount and timing of glucagon release is highly variable, and (2) glucagon rapidly fibrillates in solution, forming aggregates that are inactive. We have developed a light activated glucagon trimer, in which we have joined three glucagon molecules via light cleaved linkers. We demonstrated that this material can be stimulated by light to release glucagon in a predictable manner. In addition, we demonstrated that in the absence of light, the trimer does not form fibrils and thus releases normal unfibrillated glucagon upon ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-19T09:22:52.052Z","creation":"2025-04-19T09:22:52.052Z"},"accession":"S-EPMC8906801","cross_references":{"pubmed":["33703874"],"doi":["10.1021/acsbiomaterials.1c00031"]}}