{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Yin H"],"pubmed_abstract":["<h4>Background</h4>Adult T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignant tumor with poor prognosis. However, accurate prognostic stratification factors are still unclear.<h4>Methods</h4>Data from 90 adult T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients were collected. The association of gene mutations detected by next-generation sequencing and clinical characteristics with the outcomes of T-ALL/LBL patients were retrospectively analyzed to build three novel risk stratification models through Cox proportional hazards model.<h4>Results</h4>Forty-seven mutated genes were identified. Here, 73.3% of patients had at least one mutation, and 36.7% had ≥3 mutations. The genes with higher mutation frequency were <i>NOTCH1</i>, <i>FBXW7</i>, and <i>DNMT3A</i"],"journal":["Frontiers in oncology"],"pagination":["811151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8908046"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing."],"pmcid":["PMC8908046"],"pubmed_authors":["Yao L","Yin H","Hong M","Qian C","Li T","Wu Q","Deng J","Teng Y"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing.","description":"<h4>Background</h4>Adult T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignant tumor with poor prognosis. However, accurate prognostic stratification factors are still unclear.<h4>Methods</h4>Data from 90 adult T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients were collected. The association of gene mutations detected by next-generation sequencing and clinical characteristics with the outcomes of T-ALL/LBL patients were retrospectively analyzed to build three novel risk stratification models through Cox proportional hazards model.<h4>Results</h4>Forty-seven mutated genes were identified. Here, 73.3% of patients had at least one mutation, and 36.7% had ≥3 mutations. The genes with higher mutation frequency were <i>NOTCH1</i>, <i>FBXW7</i>, and <i>DNMT3A</i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T21:48:10.018Z","creation":"2025-04-19T21:48:10.018Z"},"accession":"S-EPMC8908046","cross_references":{"pubmed":["35280829"],"doi":["10.3389/fonc.2022.811151"]}}