biostudies-literatureUnknown12Yin H<h4>Background</h4>Adult T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignant tumor with poor prognosis. However, accurate prognostic stratification factors are still unclear.<h4>Methods</h4>Data from 90 adult T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients were collected. The association of gene mutations detected by next-generation sequencing and clinical characteristics with the outcomes of T-ALL/LBL patients were retrospectively analyzed to build three novel risk stratification models through Cox proportional hazards model.<h4>Results</h4>Forty-seven mutated genes were identified. Here, 73.3% of patients had at least one mutation, and 36.7% had ≥3 mutations. The genes with higher mutation frequency were <i>NOTCH1</i>, <i>FBXW7</i>, and <i>DNMT3A</iFrontiers in oncology811151https://www.ebi.ac.uk/biostudies/studies/S-EPMC8908046biostudies-literaturePrognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing.PMC8908046Yao LYin HHong MQian CLi TWu QDeng JTeng YfalsePrognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing.<h4>Background</h4>Adult T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignant tumor with poor prognosis. However, accurate prognostic stratification factors are still unclear.<h4>Methods</h4>Data from 90 adult T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients were collected. The association of gene mutations detected by next-generation sequencing and clinical characteristics with the outcomes of T-ALL/LBL patients were retrospectively analyzed to build three novel risk stratification models through Cox proportional hazards model.<h4>Results</h4>Forty-seven mutated genes were identified. Here, 73.3% of patients had at least one mutation, and 36.7% had ≥3 mutations. The genes with higher mutation frequency were <i>NOTCH1</i>, <i>FBXW7</i>, and <i>DNMT3A</i2022-01-01T00:00:00Z20222025-04-19T21:48:10.018Z2025-04-19T21:48:10.018ZS-EPMC89080463528082910.3389/fonc.2022.811151